Bone remodeling

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Unknown (3222)
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Organisms

Mus musculus (319)
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Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (1)
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Post-stasis (1)
Hutchinson-Gilford Progeria Syndrome (1)
S enteritidis (1)
Osteonecrosis (1)
Bone remodeling disease (1)
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Breast adenocarcinoma (1)
Bone osteosarcoma (1)
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Technology Type

Mass Spectrometry (45)
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Instrument Platform

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NA (1)
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BGISEQ-500 (1)

Publication Date

2026 (157)
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2024 (89)
2015 (76)
2010 (72)
2008 (68)
2012 (64)
2023 (55)
2013 (53)
2016 (48)
2011 (47)
2014 (44)
2022 (31)
2021 (31)
2019 (30)
2009 (24)
2007 (22)
2017 (15)
2020 (13)
2018 (12)
2006 (10)
2005 (7)
2004 (1)

UNIPROT ID/AC

W5Q0N0_SHEEP (6)
W5PQA8_SHEEP (6)
W5P707_SHEEP (6)
W5PTH1_SHEEP (6)
W5NUN8_SHEEP (6)
PLMN_SHEEP (6)
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W5P627_SHEEP (6)
AL1A1_SHEEP (6)
HBB_SHEEP (6)
ANXA2_SHEEP (6)
TTHY_SHEEP (6)
CERU_SHEEP (6)
P01270 (3)
Q13950 (2)
O00300 (2)
O14788 (2)
P16220 (2)
P10415 (2)
P01137 (2)
Q9BQB4 (1)
P09603 (1)
O15528 (1)
Q9Y6Q6 (1)
P04628 (1)
Q07812 (1)

CHEBI ID

CHEBI:15891 (6)
CHEBI:16335 (6)
CHEBI:16027 (6)
CHEBI:6650 (6)
CHEBI:30915 (6)
CHEBI:16610 (5)
CHEBI:16196 (5)
CHEBI:16704 (5)
CHEBI:15741 (5)
CHEBI:28931 (4)
CHEBI:28875 (4)
CHEBI:17295 (4)
CHEBI:16467 (4)
CHEBI:17351 (4)
CHEBI:16393 (4)
CHEBI:16015 (4)
CHEBI:28865 (4)
CHEBI:18012 (4)
CHEBI:30769 (4)
CHEBI:15354 (4)
CHEBI:17596 (4)
CHEBI:17202 (4)
CHEBI:16750 (4)
CHEBI:16856 (4)
CHEBI:17858 (4)
CHEBI:52254 (1)
CHEBI:52217 (1)
CHEBI:17823 (1)
CHEBI:35780 (1)
CHEBI:29108 (1)

Metabolite Name

Adenosine (15)
Hypoxanthine (15)
Inosine (15)
Creatine (14)
Creatinine (13)
Taurine (13)
Adenine (12)
Guanine (12)
Guanosine (12)
Uracil (11)
Choline (11)
L-Leucine (11)
Betaine (10)
Thiamine (10)
Oleamide (10)
Riboflavin (10)
L-Histidine (10)
Cytidine (10)
Uridine (10)
L-Tyrosine (9)
Hippuric acid (9)
Asparagine (9)
Spermidine (9)
Methionine sulfoxide (9)
Phenylalanine (9)
Glutamine (9)
Cytosine (9)
Valine (8)
Thymine (8)
Kynurenic acid (8)

First Public Date

2026 (142)
2025 (106)
2024 (83)
2023 (50)
2014 (46)
2022 (28)
2021 (28)
2019 (24)
2020 (16)
2015 (12)
2018 (11)
2017 (7)
2016 (6)
2013 (3)

Modelling Approach

Ordinary differential equation model (13)

Lab affiliation

Center for Translational and Clinical Research, Department of Proteomics, School of Medicine, University of Zagreb, Zagreb, Croatia Drago Perović Department of Anatomy, School of Medicine, University of Zagreb, Zagreb, Croatia (1)
Departments of Surgery and Biomedical Sciences Cedars-Sinai Medical Center (1)
Molecular Skeletal Biology Laboratory, Department of Trauma, Hand and Reconstructive Surgery, University-Medical Center Hamburg-Eppendorf, Hamburg, Germany. (1)
Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. (1)
Department of Fundamental Neurosciences University of Lausanne Rue du Bugnon 9 1005 Lausanne (1)
College of Stomatology, Chongqing Medical University,Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,China (1)
Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. (1)
Institute of Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, 55131, Germany Research Center for Immunotherapy (FZI), University Medical Center Mainz, 55131 Mainz, Germany. (1)
NMS, CEDOC, NOVA University Lisbon, Portugal (1)
3Plateforme Protéomique 3P5-Necker, Structure Fédérative de Recherche Necker and Université Paris Descartes, INSERM US24/CNRS UMS3633, Paris, (1)
Institute for Vascular Biology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria (1)
Weill Cornell Medicine (1)
School of Natural Sciences, Macquarie University, Sydney, Australia Biomolecular Discovery Research Centre, Macquarie University, Sydney, Australia Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, 464-8601, Japan (1)
1Institute of Lung Health and Immunity, Comprehensive Pneumology Center Munich with the CPC-M bioArchive, Helmholtz Center Munich, Research Center for Environmental Health, Member of the German Center of Lung Research (DZL), Germany (1)
Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant,Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Italy. (1)
Medizinische Proteom-Center 44801 Bochum, Germany (1)
Professor & Head, Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Karnataka, Manipal, 576 104, India (1)
Translational Research Centre in Onco-hematology, Faculty of Medicine, University of Geneva, and Swiss Cancer Center Leman, Geneva, Switzerland (1)
OncoProteomics Laboratory, Dept. of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (1)
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) (1)
Département d’Immunologie et Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada, (1)
Translational Matrix Biology, University of Cologne, Medical Faculty, Cologne, Germany (1)
Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands. (1)
Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK (1)
Institute for Research in Biomedicine, Baldiri i Reixac 10, Barcelona 08028, Spain (1)
Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, 130000, China (1)
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid (Spain) (1)
Shenzhen Key Laboratory of Metabolic Health，Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology，Chinese Academy of Sciences (1)
Department of Biological Engineering, MIT, Cambridge, USA Ragon Institute of Mass General, Harvard, and MIT, Cambridge, USA (1)
National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China (1)

IsPrivate

False (13)

Classification

bacteria (2)

Study type

Transcription profiling by array (306)
ChIP-seq (61)
RNA-seq of coding RNA (38)
Unknown experiment type (25)
ChIP-chip by tiling array (19)
Other (10)
Methylation profiling by high throughput sequencing (9)
RNA-seq of coding RNA from single cells (8)
ChIP-chip by array (7)
CUT&RUN (5)
Transcription profiling by RT-PCR (4)
Comparative genomic hybridization by array (4)
Methylation profiling by array (4)
DNA-seq (3)
RNA-seq of total RNA (3)
Cell line - High-throughput sequencing (2)
Transcription profiling by tiling array (2)
RNA-seq of non coding RNA (2)
MNase-seq (1)
Proteomic profiling by mass spectrometer (1)
RNAi profiling by array (1)
Bisulfite-seq (1)
ATAC-seq (1)
RIP-seq (1)

Release Date

2025 (417)
2022 (355)
2021 (344)
2023 (308)
2024 (256)
2020 (254)
2018 (208)
2019 (200)
2016 (198)
2015 (170)
2014 (151)
2017 (147)
2010 (116)
2013 (107)
2012 (106)
2026 (104)
2011 (81)
2008 (77)
2009 (58)
2007 (32)
2006 (22)
2005 (14)
2004 (5)
2003 (2)
2002 (2)
2001 (2)
2000 (2)
1999 (2)
1998 (1)
1997 (1)

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Inhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass

Recent studies have provided links between glutamine metabolism and bone remodeling, but little is known about its role in primary osteoporosis progression. We aimed to determine the effects of inhibiting glutaminase (GLS) on two types of primary osteoporosis and elucidate the related metabolism. To...

2024-06-17 | MTBLS9415 | MetaboLights

Graham2013 - Role of osteocytes in targeted bone remodeling

Jason M. Graham, Bruce P. Ayati, Sarah A. Holstein & James A. Martin. The role of osteocytes in targeted bone remodeling: a mathematical model. PLoS ONE 8, 5 (2013). Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclas...

2024-09-02 | BIOMD0000000721 | BioModels

Glycerophospholipid remodeling is critical for orthoflavivirus infection

Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile and tick-borne encephalitis viruses, as well as dengue and yellow fever virus. Early in infection specific lipids accumulated, e.g., neutral...

2025-02-24 | MTBLS11030 | MetaboLights

Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Mechanical force is critical for the development and remodeling of bone. Here we report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine (ADMA) via regulating the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 (Ddah1) expression in osteobla...

2021-11-23 | MTBLS3725 | MetaboLights

Uridine Attenuates Osteoclastogenesis and Ovariectomy Induced Bone Loss by Modulating the PI3K/Akt–FoxO ROS Signaling Axis

Osteoporosis is a metabolic bone disorder characterized by aberrant osteoclast activation, leading

to excessive bone resorption and microarchitectural deterioration. Although the interconnection

between osteoclast differentiation and cellular energy metabolism has been inc...

2026-04-09 | MTBLS13394 | MetaboLights

Proctor2016 - Circadian rhythm of PTH and the dynamics of signaling molecules on bone remodeling

Proctor2016 - Circadian rhythm of PTH and the dynamics of signaling molecules on bone remodeling This model is described in the article: Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing. Proctor CJ, Gartland A. Front Endocrinol (L...

2024-09-02 | BIOMD0000000612 | BioModels

Peterson2010 - Integrated calcium homeostasis and bone remodelling

Peterson2010 - integrated calcium homeostasis and bone remodelling This model is described in the article: A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling. Peterson MC, Riggs MM. Bone 2010 Jan; 46(1): 49-63 Abstract: ...

2024-09-02 | BIOMD0000000613 | BioModels

Arsenic induces metabolome remodeling in mature human adipocytes

Human lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the deve...

2025-05-23 | MTBLS8808 | MetaboLights

Involvement of serum-derived exosomes of patients with low bone density in progressive failure of bone remodeling via alteration of intercellular signal transduction and integrin-mediated mechanosensation

Exosomes are secreted into the blood by various types of cells. These small vesicles are involved in bone remodeling by mediation of intercellular communication in osteoblasts, osteoclasts or their precursors. Alterations in exosomal proteins are related to the failure of bone remodeling, which resu...

ORGANISM(S): Homo sapiens (Human)

2018-04-09 | PXD006463 | Pride

Lemaire2004 - Role of RANK/RANKL/OPG pathway in bone remodelling process

This a model from the article: Modeling the interactions between osteoblast and osteoclast activities in bone remodeling. Lemaire V, Tobin FL, Greller LD, Cho CR, Suva LJ. J Theor Biol.2004 Aug 7;229(3):293-309. 15234198, Abstract: We pr...

2024-09-02 | BIOMD0000000278 | BioModels

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