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MetabolomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to st...

2025-04-25 | MTBLS12329 | MetaboLights
TranscriptomicsHuman mitochondria hub of small RNAs: Analysis by deep Sequencing
We report here that human mitochondria contain small RNA including microRNA, piRNA, tRNA, rRNA, and RNA repeats. Mitochondria from human cells were purified and RNA isolated. Small RNAs were purified, library generated and analyzed by Illumina Hiseq 2000 system. The sequencing generated 19.5 and 17....
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-32185 | biostudies-arrayexpress
ProteomicsTop-Down proteomics of unfractionated Bovine heart mitochondria
Top-Down proteomics pilot experiment of unfractionated Bovine Heart Mitochondria (BHM) using ultra high resolution Q-ToF tandem mass spectrometry (maXis 4G ETD, Bruker Daltonics).
ORGANISM(S): Bos taurus (Bovine) 
2018-04-05 | PXD005350 | Pride
Bovine Mitochondrion Protein Intact Top-down proteomics 
ProteomicsPROTEOME OF BOVINE MITOCHONDRIA AND ROD OUTER SEGMENT DISKS: COMMONALITIES AND DIFFERENCES.
The retinal rod outer segment (OS) isa stack of diskssurrounded by the plasma membrane,housing proteins related to phototransduction as well asmitochondrial proteins involved in oxidative phosphorylation (OxPhos). This prompted us to compare the proteome of bovine OS disks and mitochondria, to asses...
ORGANISM(S): Bos taurus (Bovine) 
2022-03-01 | PXD008087 | Pride
Atp synthase  disks electron transfer chain  mass spectrometry  mitochondria  oxidative phosphorylation  rod outer segment  transmission electron microscopy. 
ProteomicsThe inhibitor protein IF1 from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex
The hydrolytic activity of the ATP synthase in bovine mitochondria is inhibited by a protein called IF1, but bovine IF1 has no effect on the synthetic activity of the bovine enzyme in mitochondrial vesicles in the presence of a proton motive force. As part of an investigation into the inhibitory eff...
ORGANISM(S): Bos taurus (Bovine) 
2024-01-29 | PXD045079 | Pride
Bovine mitochondria Atp synthase If1 protein Absolute quantification 
TranscriptomicsInferring the in vivo cellular program of developing bovine muscle from expression data
We outline an in vivo cellular program of bovine longissimus muscle development inferred from expression data from 60 days post conception to 3 months postnatal. Analytic challenges included changes in cellular composition, ambiguous ‘diagnostic’ markers of cell type and contrasts between cattle hum...
ORGANISM(S): Bos taurus 
2013-02-03 | E-GEOD-44030 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of immunocaptured mitochondria from Astrocytes
Mitochondria vary in morphology and function in different tissues, however little is known about their molecular diversity among cell types. To investigate mitochondrial diversity in vivo, we developed an efficient protocol to isolate cell type-specific mitochondria based on a new MitoTag mouse. We ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD010781 | Pride
Astrocytes Mitochondria 
UnknownPreimplantation death of xenomitochondrial mouse embryo harbouring bovine mitochondria.
Not available
S-EPMC4586891 | biostudies-literature
ProteomicsQuantitative proteomics of immunocaptured mitochondria from Granule cells
Mitochondria vary in morphology and function in different tissues, however little is known about their molecular diversity among cell types. To investigate mitochondrial diversity in vivo, we developed an efficient protocol to isolate cell type-specific mitochondria based on a new MitoTag mouse. We ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD010774 | Pride
Mitochondria Granule cells Neurons 
ProteomicsQuantitative proteomics of immunocaptured mitochondria from Purkinje Cells
Mitochondria vary in morphology and function in different tissues, however little is known about their molecular diversity among cell types. To investigate mitochondrial diversity in vivo, we developed an efficient protocol to isolate cell type-specific mitochondria based on a new MitoTag mouse. We ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD010772 | Pride
Mitochondria Purkinje cells Neurons 
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