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TranscriptomicsActivator protein-2γ is a critical determinant of estrogen receptor interactome formation and gene transcription in breast cancer [expression]
Estrogen receptor α (ERα) is key player in the progression of breast cancer. ERα binds to DNA and mediates long-range chromatin interactions throughout the genome, but the underlying mechanism in this process is unclear. Here, we show that AP-2 motifs are highly enriched in the ERα binding sites...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-26740 | biostudies-arrayexpress
GenomicsActivator protein-2M-NM-3 is a critical determinant of estrogen receptor interactome formation and gene transcription in breast cancer [ChIP-Seq]
Estrogen receptor M-NM-1 (ERM-NM-1) is key player in the progression of breast cancer. ERM-NM-1 binds to DNA and mediates long-range chromatin interactions throughout the genome, but the underlying mechanism in this process is unclear. Here, we show that AP-2 motifs are highly enriched in the ERM-NM...
ORGANISM(S): Homo sapiens 
2011-06-03 | E-GEOD-23852 | biostudies-arrayexpress
UnknownChromatin interactome mapping at 139 independent breast cancer risk signals.
Not available
S-EPMC6947858 | biostudies-literature
ProteomicsEstrogen Receptor alpha and Histone Lysine Methyltransferase DOT1L chromatin bound interactome
Estrogen Receptor alpha (ERα) is a ligand-inducible transcription factor that mediates estrogen signaling in hormone-responsive breast cancer (BC) and is the primary target of specific anticancer therapies. Although ERα blockade with these drugs is effective, the development of a resistance to treat...
ORGANISM(S): Homo sapiens (Human) 
2019-02-09 | PXD010314 | Pride
Estrogen receptor alpha Estrogen signaling Breast cancer chromatin interactome Dot1l Lc-ms/ms 
ProteomicsA quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes
Understanding the dynamics of endogenous protein-protein interactions in complex networks is pivotal in deciphering the mechanisms underlying diseases such as cancer. To enable the in-depth analysis of protein interactions in chromatin-associated protein complexes, we have previously developed a met...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD007968 | Pride
Breast cancer Proteomics Qplex-rime Tmt 4-hydrotamoxifen Rime Clinical samples Isobaric labelling Patient derived xenografts (pdx) Estrogen receptor alpha Interactome 
GenomicsAn Estrogen Receptor α-bound Human Chromatin Interactome
We developed Chromatin Interaction Analysis by Paired-End Tag sequencing (ChIA-PET) for de novo detection of global chromatin interactions, and comprehensively mapped the chromatin interaction network bound by estrogen receptor α (ERα) in the human genome. We performed 454 and Illumina sequencing an...
ORGANISM(S): Homo sapiens 
2009-09-11 | E-GEOD-18046 | biostudies-arrayexpress
UnknownMapping the FOXA1 Interactome in ER+ Breast Cancer Cells Using Proximity Labeling Reveals Novel Interactions with the Orphan Nuclear Receptor NR2C2.
Not available
S-EPMC12477713 | biostudies-literature
ProteomicsFOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer
The forkhead protein FOXA1 has been found to play a critical role in orchestrating hormonal-signaling network and to function as a pioneer factor to regulate breast-specific gene expression,However, whether interplay between O-GlcNAcylation and FOXA1 affects the genome-wide transcriptional activity ...
ORGANISM(S): Homo Sapiens 
2022-12-21 | PXD039019 |
UnknownNuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer.
Not available
S-EPMC8338892 | biostudies-literature
UnknownCapture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.
Not available
S-EPMC4346635 | biostudies-literature
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