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TranscriptomicsPolygenic and directional regulatory evolution across pathways in Saccharomyces
We assess the prevalence of polygenic evolution in pathways between the yeasts S. cerevisiae and S. bayanus. We first established short-read sequencing methods to detect cis-regulatory variation in a diploid hybrid between the species. We then formulated an analytic strategy to test for the scenar...
ORGANISM(S): Saccharomyces bayanus x Saccharomyces cerevisiae 
2010-02-22 | E-GEOD-19837 | biostudies-arrayexpress
TranscriptomicsExpression evolution in gene groups: Inferring non-neutral regulatory change in pathways from transcriptional profiling data
We profiled the transcriptomes of four Saccharomyces species, as well as pairwise hybrids between three of the species with S. cerevisiae For pairwise comparisons between Saccharomyces cerevisiae and each of S. paradoxus, S. mikatae, and S. bayanus, we performed 3'-end RNA-seq on RNA from each paren...
ORGANISM(S): Saccharomyces cerevisiae x Saccharomyces mikatae 
2013-10-21 | E-GEOD-38875 | biostudies-arrayexpress
TranscriptomicsThe genetics and regulatory logic of alternative polyadenylation in human lymphoblastoid cells
We set out to investigate genomic mechanisms by which alternative polyadenylation impacts gene expression and its variation across genetically distinct human individuals. We used 3’-end RNA-seq to maximize genome coverage and precision of transcript end positions, and to measure quantitative express...
ORGANISM(S): Homo sapiens 
2012-08-27 | E-GEOD-33154 | biostudies-arrayexpress
TranscriptomicsTrans-acting regulatory variation in Saccharomyces cerevisiae
Natural genetic variation can cause significant differences in gene expression, but little is known about the polymorphisms that affect gene regulation. We analyzed regulatory variation in a cross between laboratory and wild strains of Saccharomyces cerevisiae. Clustering and linkage analysis define...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-617 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and genotyping, detection of allele specific gene expression of Saccharomyces BY, isogenic to S288C, and RM, a wild vineyard strain
By hybridizing mRNA to oligonucleotide arrays and searching for probes that are outliers in their probe set, we identify and genotype polymorhisms in two strains of yeast (BY, isogenic to S288C, and RM, a wild vineyard strain) and segregants from a cross between the two strains. We then use this mR...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-11 | E-GEOD-1975 | biostudies-arrayexpress
TranscriptomicsReconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells: RNA-seq
Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on a cellular hierarchy reminiscent of normal development but superimposed on underlying genetic abe...
ORGANISM(S): Homo sapiens 
2014-04-14 | E-GEOD-54791 | biostudies-arrayexpress
TranscriptomicsTranscriptional impact of removing H2A.Z
We profiled the strand-specific transcriptome of Saccharomyces cerevisiae lacking SWR1 and HTZ1 and compared it to the wild-type transcriptome 3'-end RNA-seq was performed on RNA from Saccharomyces cerevisiae wild-type and swr1 htz1 strains (two biological replicates each)
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-01 | E-GEOD-46535 | biostudies-arrayexpress
UnknownPolygenic and directional regulatory evolution across pathways in Saccharomyces.
Not available
S-EPMC2841874 | biostudies-literature
UnknownPolygenic evolution of a sugar specialization trade-off in yeast.
Not available
S-EPMC4760848 | biostudies-literature
UnknownDivergence of Peroxisome Membrane Gene Sequence and Expression Between Yeast Species.
Not available
S-EPMC7263690 | biostudies-literature
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