Sort   by:  
 Page size 
ProteomicsAsparagine hydroxylation of the UBA domain in Cezanne (OTUD7B)
by DUBs need to be tightly controlled. Here, we identify asparagine hydroxylation as a novel posttranslational modification involved in the regulation of Cezanne (OTUD7B), a DUB that controls key cellular functions and signaling pathways. We demonstrate that Cezanne is a substrate for FIH1- and oxyg...
ORGANISM(S): Homo sapiens (Human) 
2020-01-24 | PXD015216 | Pride
Otu7b Deubiquitinases Hydroxylation Cezanne 
ProteomicsLAMTOR1 interactome upon knock out of USP32
Ubiquitination is among the most prevalent post-translational modifications regulating a great number of cellular functions, and defects in such processes contribute to many diseases. Deubiquitinating enzymes (DUBs) are essential to control the precise outcome of ubiquitin signals. The ubiquitin-spe...
ORGANISM(S): Homo sapiens (Human) 
2023-01-16 | PXD024940 | Pride
Q exactive hf Lfq Lamtor1 Ubiquitin Usp32 Lc-ms/ms 
ProteomicsLAMTOR1 interactome upon mutation of USP32
Ubiquitination is among the most prevalent post-translational modifications regulating a great number of cellular functions, and defects in such processes contribute to many diseases. Deubiquitinating enzymes (DUBs) are essential to control the precise outcome of ubiquitin signals. The ubiquitin-spe...
ORGANISM(S): Homo sapiens (Human) 
2023-01-16 | PXD035974 | Pride
Rpe1 Interactome Lamtor1 Usp32 
ProteomicsUSP32 regulates non-proteolytic LAMTOR1 ubiquitination and Ragulator function
Ubiquitination is among the most prevalent post-translational modifications regulating a great number of cellular functions, and defects in such processes contribute to many diseases. Deubiquitinating enzymes (DUBs) are essential to control the precise outcome of ubiquitin signals. The ubiquitin-spe...
ORGANISM(S): Homo sapiens (Human) 
2022-12-16 | PXD024227 | Pride
Lysosomes Ubiquitin 
ProteomicsUSP32 regulates non-proteolytic LAMTOR1 ubiquitination and Ragulator function
Ubiquitination is among the most prevalent post-translational modifications regulating a great number of cellular functions, and defects in such processes contribute to many diseases. Deubiquitinating enzymes (DUBs) are essential to control the precise outcome of ubiquitin signals. The ubiquitin-spe...
ORGANISM(S): Homo sapiens (Human) 
2022-12-16 | PXD024211 | Pride
Ubiquitin Digly Lysosome 
ProteomicsVersatile regulation of autophagy by the deubiquitinase USP11
Ubiquitination is a versatile post-translational modification known to regulate autophagy. Here, we show that loss of the deubiquitinase USP11 leads to an increase in the autophagic flux. To investigate the molecular details of how USP11 impacts autophagy, we determined interaction partners of USP11...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD022143 | Pride
Ubiquitination Autophagy Usp11 
Sort   by:  
 Page size