Bromodomain containing protein 4

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Unknown (312)
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Organisms

Homo sapiens (62)
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Repository

biostudies-arrayexpress (148)
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geo (72)
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Acute leukemia (2)
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Mass Spectrometry (20)
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Liquid Chromatography MS - alternating - hilic (1)
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2016 (41)
2014 (39)
2015 (35)
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2020 (10)
2012 (9)
2018 (8)
2021 (8)
2022 (6)
2010 (6)
2019 (6)
2017 (6)
2011 (3)
2008 (2)
2009 (1)

Metabolite Name

Hexenoylcarnitine (Car(6:1)) (1)
4-(Dimethylamino)pyridine (1)
1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine (1)
N-Oleoyl-D-erythro-sphingosylphosphorylcholine (1)
Arsenobetaine (1)
L-Norvaline (1)
Oxotetradecadienoylcarnitine (Car(14:3-O)) (1)
1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine (1)
Imiquimod (1)
[(Aminocarbonyl)(methyl)amino]acetic acid (1)
2-(2-Aminoethoxy)acetic acid (1)
Alpinetin (1)
2-Amino-3-methyl-imidazo[4,5-f]quinoline (IQ) (1)
1-Docosahexaenoyl-2-stearoyl-sn-glycero-3-phosphocholine (1)
Dihydrotachysterol (1)
Azeliragon (1)
Picoline (1)
Aminopicoline (1)
Tiglylcarnitine (Car(5:1)) (1)
Cysteine S-sulfate (1)
Fenobucarb (1)
Dibenzylamine (1)
Pyrimethanil (1)
N-Nitrosopyrrolidine (1)
Oxooctanoylcarnitine (Car(8:1-O)) (1)
.beta.-D-Glucopyranosiduronic acid, 4-(7-hydroxy-4-oxo-4H-1-benzopyran-3-yl)phenyl (1)
Tetradecenedioylcarnitine (Car(14:1-O2)) (1)
Perifosine (1)
1-Octadecylamine (1)
1-O-Hexadecyl-2-O-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glyceryl-3-phosphorylcholine (1)

First Public Date

2023 (19)
2025 (9)
2021 (8)
2020 (8)
2016 (8)
2026 (6)
2024 (6)
2014 (5)
2017 (4)
2018 (3)
2019 (2)
2022 (1)
2015 (1)
2013 (1)

Classification

protozoa (1)

Study type

ChIP-seq (59)
Transcription profiling by array (46)
RNA-seq of coding RNA (34)
Other (3)
ChIP-chip by tiling array (2)
Unknown experiment type (1)
Animal - High-throughput sequencing (1)
Genotyping by array (1)
Methylation profiling by high throughput sequencing (1)

Release Date

2016 (44)
2015 (41)
2014 (41)
2022 (39)
2021 (36)
2024 (35)
2023 (33)
2020 (32)
2025 (31)
2018 (26)
2013 (25)
2019 (19)
2017 (16)
2012 (13)
2026 (8)
2010 (8)
2011 (4)
2009 (4)
2008 (2)
2007 (1)
2001 (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Dept. of Molecular Biosciences, University of Texas at Austin, Texas 78712 USA (2)
Francis Crick Institute 1 Midland Road London NW1 1AT (2)
CRCL UMR Inserm U1052, CNRS 5286, UCBL, CLB (1)
CeMM, Research Center for Molecular Medicine, Austrian Academy of Sciences, Austria (1)
Institute for Clinical and Translational Research (ICTR), University of Wisconsin-Madison, Madison, WI, 53705, USA (1)
Institute for Clinical and Translational Research, University of Wisconsin - Madison (1)
Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology (1)
Laboratory of Systems Biology, University of Warsaw (1)
Medicinal Chemistry, Monash Institute of Pharmaceutica Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia (1)
Professor • Centre for Targeted Protein Degradation (1)
Proteomics Facility, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany (1)
Proteomics Unit, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro 3. E28029 MADRID, SPAIN. Phone +34 912246900 ext 3112 (1)
Roivant sciences, Discovery Platform, Advanced simulations, New York City, NY (1)
Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research and Jewish General Hospital, and McGill University, Montréal, Québec, Canada Gerald Bronfman Department of Oncology, McGill University, Montréal, Québec, Canada (1)
Structural and Computational Biology Unit European Molecular Biology Laboratory Meyerhofstr. 1 69117 Heidelberg Germany (1)
University of Texas Medical Branch (1)

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Bromodomain-Containing-Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells

Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with Bromodomain-containing protein 4 (BRD4). We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-...

ORGANISM(S): Homo sapiens

2012-11-14 | E-GEOD-33281 | biostudies-arrayexpress

Identification of a novel Bromodomain / Casein Kinase II / TAF-containing complex as a regulator of mitotic condensin function

ABSTRACT: Condensin is a central regulator of mitotic genome structure, with mutants showing poorly condensed chromosomes and profound segregation defects. Here we identify the fission yeast NCT complex, comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02), Casein Kinase II (CKII) ...

ORGANISM(S): Schizosaccharomyces pombe

2014-01-10 | E-GEOD-53955 | biostudies-arrayexpress

Brd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release

Distal enhancers characterized by H3K4me1 mark play critical roles in developmental and transcriptional programs. However, potential roles of specific distal regulatory elements in regulating RNA Polymerase II (Pol II) promoter-proximal pause release remain poorly investigated. Here we report that a...

ORGANISM(S): Homo sapiens

2014-01-14 | E-GEOD-51633 | biostudies-arrayexpress

Super-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins

Here, we investigate the role of enhancers in myofibroblasts, a cell type that dominates the pathogenesis and progression of tissue fibrosis. We reveal that bromodomain and extra-terminal family members (BETs), an important group of epigenetic readers, are critical for super-enhancer-mediated pro-fi...

ORGANISM(S): Homo sapiens

2015-12-11 | E-GEOD-58680 | biostudies-arrayexpress

H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription

Hormone-dependent gene expression requires dynamic and coordinated epigenetic changes. Estrogen receptor-positive (ER+) breast cancer is particularly dependent upon extensive chromatin remodeling and changes in histone modifications for the induction of hormone-responsive gene expression. Our previo...

ORGANISM(S): Homo sapiens

2015-05-02 | E-GEOD-65886 | biostudies-arrayexpress

Bromodomain-containing protein 2 (BRD2) interactome in ES cells

Identification of Bromodomain-containing protein 2 (BRD2) interaction partners using liquid-chromatography based mass spectrometry in murine embryonic stem cells (ESC), using BRD2 endogenously tagged with a mAID-V5 tag.

ORGANISM(S): Mus musculus (Mouse)

2026-04-22 | PXD072982 | Pride

Streptococcus anginosus promotes hepatocellular carcinoma progression and BET inhibitor resistance by inducing BRD4 lactylation

Hepatocellular carcinoma (HCC) is a highly aggressive form of carcinoma with a poor prognosis. Diagnostic markers and potential therapeutic targets for HCC are urgently needed. Here, we demonstrate that fecal microbiota transplantation (FMT) using stool samples from HCC patients significantly pro...

2025-12-05 | MTBLS12398 | MetaboLights

Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhage.

Not available

S-EPMC12220699 | biostudies-literature

Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming (ChIP-seq)

Reactivation of the pluripotency network during somatic cell reprogramming by exogenous transcription factors involves chromatin remodeling and the recruitment of RNA polymerase II (Pol II) to target loci. Here, we report that Pol II is engaged at pluripotency promoters in reprogramming but remains ...

ORGANISM(S): Mus musculus

2014-10-07 | E-GEOD-59828 | biostudies-arrayexpress

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

PRJNA760319 | ENA

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653 Results

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