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ProteomicsGlobal profiling of myristoylation in Toxoplasma gondii
N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens. Here we describe the first global chemoproteomic analysis of protein myristoylation in Toxoplasma gondii. Through quan...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2020-07-06 | PXD019677 | Pride
N-myristoylation Chemical proteomics Toxoplasma Nmt inhibition 
ProteomicsAn Exported Kinase Family Mediates Species-Specific Erythrocyte Remodelling and Virulence in Human Malaria
The most severe form of human malaria is caused by Plasmodium falciparum. Its virulence is closely linked to the increase in rigidity and cytoadhesion of infected erythrocytes, which obstruct blood flow to vital organs. Unlike other human-infecting Plasmodium species, P. falciparum exports a family ...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) Plasmodium knowlesi strain H 
2020-04-17 | PXD015833 | Pride
Plasmodium Fikk kinases Malaria Red blood cell Phosphorylation 
OtherMultifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development.
Data from ProteomeXchange, PXD ID: PXD001863. File: HEK_HeLa_MCF_ PEAKS7.mgf. Published as part of Angew Chem Int Ed Engl. 2015 Mar 25 . From the Abstract: {{i}} Novel multifunctional reagents were applied in combination with a lipid probe for affinity enrichment of myristoylated proteins and direc...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320014414 | GPMDB
Resource Reanalysis 
ProteomicsA positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signaling in Toxoplasma gondii.
Fundamental processes of obligate intracellular parasites, such as Plasmodium falciparum and Toxoplasma gondii are controlled by a set of plant-like calcium dependent kinases (CDPKs), the conserved cAMP- and cGMP-dependent protein kinases (PKA and PKG), second messengers and lipid signalling. While ...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2022-10-17 | PXD030057 | Pride
Toxoplasma gondii Calcium-signalling Egress Cdpk3 
ProteomicsDifferential protein phosphorylation during stage conversion in Toxoplasma gondii
The intracellular parasite Toxoplasma gondii resides within a membrane bound parasitophorous vacuole and secretes an array of proteins to establish this replicative niche during acute stage of infection. When rapidly dividing tachyzoites convert to chronic stage bradyzoites, many secreted proteins a...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii ME49 
2020-06-12 | PXD019729 | Pride
Stage conversion Bradyzoites Phosphorylation Tachyzoites Toxoplasma 
ProteomicsHYPE mediated AMPylation profiling in human lysates
We describe here the first example of global chemoproteomic screening and substrate validation for HYPE mediated AMPylation in mammalian cell lysate. Through quantitative mass spectrometry-based proteomics coupled with novel chemoproteomic tools providing MS/MS evidence of AMP modification we identi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080782 | MassIVE
ProteomicsIdentification of myristoylated proteins in Human cell lines (HEK293, HeLa, MCF7)
Multi-functional capture reagents reported here enable robust identification of metabolically-tagged myristoylated proteomes with unprecedented confidence resulting from the combination of chemical probe-based enrichment, and release and direct detection of lipid-modified peptides by MS. Whilst capt...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080690 | MassIVE
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