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MetabolomicsMulti-omics analysis of thermogenic lipolysis in brown adipocytes

The integration of omics technologies into molecular biological research has transformed it into a field where a system can be investigated as a whole by combining information from multiple biochemical layers. This extension of traditional molecular biology, where various data sources are conside...

2025-11-12 | MTBLS12307 | MetaboLights
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
GenomicsChIP-seq based genome wide profiling of the histone mark H3K27ac and transcription factor Nuclear Factor 1 (NFI) in a differentiating murine brown preadipocyte cell line (IBA)
ChIP sequencing was used to generate genome-wide maps of the histone mark H3K27ac during in vitro differentiation of a murine brown preadipocyte cell line (IBA) at five different time points, in two biological replicates: Day 0 (confluence), 2h (post induction), Day 1, Day 2 and Day 4 (mature brown ...
ORGANISM(S): Mus musculus 
2017-09-21 | E-MTAB-5159 | biostudies-arrayexpress
TranscriptomicsPhysiological functions of the RORs in brown adipose tissue
To determine the physiological targets of the RORs in brown adipose tissue. Keywords: Nuclear receptors, RORs, adipose Gene expression analysis was conducted using Agilent whole mouse genome arrays (012694). The analysis was perfomed in duplicate, employing a fluor reversal. RNA was isolated from in...
ORGANISM(S): Mus musculus 
2008-12-18 | E-GEOD-9969 | biostudies-arrayexpress
TranscriptomicsmRNA-seq based gene expression profiling of differentiating murine brown preadipocytes (IBA)
mRNA-sequencing was used to profile temporal changes in gene expression during in vitro differentiation of IBA at five different time points: Day 0 (confluence), 2h (post induction), Day 1, Day 2 and Day 4 (mature brown adipocytes), performed in two biological replicates (with two technical replicat...
ORGANISM(S): Mus musculus 
2017-10-14 | E-MTAB-5160 | biostudies-arrayexpress
ProteomicsMulti-omics analysis of thermogenic lipolysis in brown adipocytes
The integration of omics technologies into molecular biological research has transformed it into a field where a system can be investigated as a whole by combining information from multiple biochemical layers. This extension of traditional molecular biology, where various data sources are considered...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-22 | PXD061570 | Pride
Transomics Brown adipocytes Lipolysis Proteomics Thermogenesis Metabolomics Lc-ms Gc-ms Transcriptomics Multi-omics 
TranscriptomicsBarcoded mRNA-seq of murine brown preadipocytes (IBA) upon transcriptomic perturbation
Loss of function assays were performed in differentiating IBAs using short hairpin RNAs (shRNAs) against a set of candidate transcription factors: NFIA, DBP, HOXA4, ZFP467, SOX18, ELF3, YBX2 and PPARa. Gene expression profiles of the perturbed and non perturbed (controls including non transduced cel...
ORGANISM(S): Mus musculus 
2017-09-21 | E-MTAB-5161 | biostudies-arrayexpress
TranscriptomicsGene expression from mouse white, brown, and perivascular adipose tissue
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome. Surprisingly, PVAT has been reported to share characteristics of both brown and white adipose, but a detailed direct co...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-28440 | biostudies-arrayexpress
TranscriptomicsConcomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma
Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor ...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-19040 | biostudies-arrayexpress
TranscriptomicsExpression data from C2C12 myoblasts transduced with PRDM16 or vector
PRDM16 is a 140 kDa transcriptional coregulatory protein. PRDM16 has been shown to function as a bi-directional switch in brown fat cell fate by stimulating the development of brown fat cells from myf-5 positive myoblastic precursors. We used microarrays to detail the global programme of gene expres...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15895 | biostudies-arrayexpress
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