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ProteomicsA photo-cleavable surfactant for top-down proteomics
We report the discovery of a photo-cleavable anionic surfactant, 4-hexylphenylazosulfonate (Azo) that can be rapidly degraded upon UV irradiation, for top-down proteomics. Azo can effectively solubilize proteins with performance comparable to SDS and is mass spectrometry (MS)-compatible. Azo-aided ...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2019-03-29 | PXD010825 | Pride
Lc-msms 
ProteomicsTop-down Proteomics of Endogenous Membrane Proteins Enabled by A Cloud Point Enrichment and Multidimensional Liquid Chromatography-Mass Spectrometry Top-down Proteomics of Endogenous Membrane Proteins Enabled by A Cloud Point Enrichment and Multidimensional Liquid Chromatography-Mass Spectrometry
Top-down proteomics has emerged as a powerful strategy to characterize proteins in biological systems. Nevertheless, the analysis of endogenous membrane proteins is challenging due to their low solubility, low abundance, and the complexity of the membrane subproteome. Here, we report a simple, effec...
ORGANISM(S): Homo sapiens (Human) 
2020-11-30 | PXD019368 | Pride
Membrane protein Top-down proteomics Cloud point 
ProteomicsRIPK3 is released into Extracellular Vesicles during Necroptosis through a Rab27 independent mechanism
Extracellular vesicles (EVs) are important mechanisms used by cells to release biomolecules. A common necroptosis effector— mixed lineage kinase like (MLKL)--- was recently found to participate in the biogenesis of small and large EVs independent of its function in necroptosis. The objective of the ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-14 | PXD031224 | Pride
Lysosomal exocytosis Ripk3 Sevs Mlkl Necroptosis Proteomics 
ProteomicsProteomics Analysis Reveals differences in Differencial Expressed Proteins Between Cardiopathic LMNA utations
Quantitative proteomics of HEK293 cell expressing LMNA mutations
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD045092 | Pride
Heart Lamin Lcms Cardiomyopathy 
ProteomicsHuman HEK293T and Pig cardiac top-down proteomes from Bruker maXis II
These data, derived from PXD019368 (PMID 33231430) and PXD010825 (PMID 30988469) represent a test of deconvolution algorithms for top-down proteomics experiments on the Bruker maXis II Q-TOF. Three LC-MS/MS experiments are available from pig cardiac tissue in both raw .d directories and in deconvol...
ORGANISM(S): Sus Scrofa (ncbitaxon:9823) Homo Sapiens (ncbitaxon:9606) 
2022-04-13 | MSV000089252 | MassIVE
ProteomicsTop-down proteome of de-fatted Bos taurus milk from an animal with clinical mastitis
Quarter-milk samples were collected from a cow with clinical mastitis on day 13 and day 16 postpartum. Milk was collected from a clinical quarter with signs of abnormality (i.e., flakes, clots, blood) and one normal quarter of the same animal. Milk samples were processed with the MPLEx protocol (ht...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2022-02-09 | MSV000088805 | MassIVE
ProteomicsUltrafast and Reproducible Proteomics from Small amounts of Heart Tissue Enabled by Azo and timsTOF Pro
Data for the manuscript "Ultrafast and Reproducible Proteomics from Small amounts of Heart Tissue Enabled by Azo and timsTOF Pro".
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-21 | MSV000087476 | MassIVE
TranscriptomicsDevelopment of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection
Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understand Mechanisms of Chemical Toxicity and Action These data support the publication titled "Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understa...
ORGANISM(S): Rattus norvegicus 
2005-05-31 | E-GEOD-2409 | biostudies-arrayexpress
UnknownVariability of Clinical Metrics in Small Population Communities Drive Perceived Wastewater and Environmental Surveillance Data Quality: Ontario, Canada-Wide Study.
Not available
S-EPMC11998010 | biostudies-literature
UnknownComponents of Adolescent Behavioural Interventions With Eating Disorder Outcomes: Systematic Review With Intervention Mapping.
Not available
S-EPMC12690354 | biostudies-literature
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