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ProteomicsNon-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis
Paracetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is fulminant necrotic cell death, resulting in acute liver failure and mortality. Here, we studied this switch of cell death modes and demonstrate a...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-24 | PXD045034 | Pride
Apap Hepatotoxicity Paracetamol Necrosis 
ProteomicsDrug-induced oxidative stress actively prevents caspase activation and hepatocyte apoptosis
Cell death is a fundamental process for health and disease. Emerging research unveiled numerous distinct cell death modalities with similar and intertwined signaling pathways, but different outcomes, rising the need to understand the decision points during cell death signaling. Paracetamol (Acetamin...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-24 | PXD050155 | Pride
Glutathione Paracetamol/apap Necrosis Oxidative stress Apoptosis Caspases 
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.
Not available
S-EPMC12519944 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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