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GenomicsExpression data of the livers of male C57Bl6/N mice after i.p. injection of paracetamol (APAP)
Expression data of the livers of male C57Bl6/N mice after i.p. injection of paracetamol (APAP)
PRJNA702769 | ENA
TranscriptomicsExpression data of the livers of male C57Bl6/N mice after i.p. injection of paracetamol (APAP)
Male C57BL6/N mice were obtained from Janvier Labs (France). Mice were starved overnight before APAP administration and were fed ad libitum afterward. A single dose of 300 mg APAP/kg b.w. was intraperitoneally injected in warm phosphate-buffered saline (PBS; Table 3). The used APAP was obtained from...
ORGANISM(S): Mus musculus 
2021-06-30 | GSE167032 | GEO
UnknownAcetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.
Not available
S-EPMC9113793 | biostudies-literature
ProteomicsNon-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis
Paracetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is fulminant necrotic cell death, resulting in acute liver failure and mortality. Here, we studied this switch of cell death modes and demonstrate a...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-24 | PXD045034 | Pride
Apap Hepatotoxicity Paracetamol Necrosis 
ProteomicsDrug-induced oxidative stress actively prevents caspase activation and hepatocyte apoptosis
Cell death is a fundamental process for health and disease. Emerging research unveiled numerous distinct cell death modalities with similar and intertwined signaling pathways, but different outcomes, rising the need to understand the decision points during cell death signaling. Paracetamol (Acetamin...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-24 | PXD050155 | Pride
Glutathione Paracetamol/apap Necrosis Oxidative stress Apoptosis Caspases 
ProteomicsReactive Metabolite-induced Protein Glutathionylation Mechanistically Accounts for Acetaminophen Hepatotoxicity
Although covalent protein binding is established as the pivotal event underpinning acetaminophen (APAP) toxicity, its mechanistic details remain unclear. In this study, we demonstrated that APAP induces widespread protein glutathionylation in a time-, dose- and bioactivation-dependent manner in Hepa...
ORGANISM(S): Homo Sapiens (human) 
2018-09-20 | PXD009986 | JPOST Repository
TranscriptomicsGene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples
In this study we conducted transcriptomics analyses of: (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (n=3) and from healthy livers (n=2) and (ii) hepatic cell systems exposed to acetaminophen, including their respective vehicle controls. The investigated i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74000 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration
Effect of vehicle vs non-toxic and toxic paracetamol (151mg/kg and 529mg/kg) doses on the gene expression profile at 1, 4 and 24h in murine liver.
ORGANISM(S): Mus musculus 
2004-02-20 | E-MEXP-82 | biostudies-arrayexpress
ProteomicsPASS00589 - Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues
The data set repersents a fair comparison of shotgun proteomics with HRM (swath type DIA). Additionally, a human liver microtissue was profiled with HRM.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-12-19 | MSV000081828 | MassIVE
TranscriptomicsSpatially-restricted and ontogenically-distinct hepatic macrophages are required for tissue repair.
Analysis of single cell RNA-seq, CITE-seq data and bulk RNA-seq data on cells isolated from the livers of mice following PBS and APAP (paracetamol/acetaminophen) administration. Spatial Transcriptomics analysis was performed using 10x Visium platform on mouse livers 48hrs post PBS or APAP administra...
ORGANISM(S): Mus musculus 
2024-10-30 | GSE280652 | GEO
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