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TranscriptomicsThe RNA binding protein Arrest (Aret) regulates myofibril maturation in Drosophila flight muscle
In Drosophila, fibrillar flight muscles (IFMs) enable flight, while tubular muscles mediate other body movements. Here, we use RNA-sequencing and isoform-specific reporters to show that spalt major (salm) determines fibrillar muscle physiology by regulating transcription and alternative splicing of ...
ORGANISM(S): Drosophila melanogaster 
2014-12-23 | E-GEOD-63707 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Bruno-3 gain of function in Drosophila larval muscles
Myotonic dystrophy type 1 (DM1) is a neuro-muscular disorder caused by CTG triplet expansion in the 3'-UTR of the DMPK gene. Mutated transcripts aggregate in muscle nuclei and increase CUGBP1 stability by a not-yet determined mechanism. To assess the involvement of CUGBP1 in DM1, we used Drosophila ...
ORGANISM(S): Drosophila melanogaster 
2017-03-24 | E-MTAB-3231 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins
The human malaria parasite Plasmodium falciparum employs intricate post-transcriptional regulatory mechanisms in different stages of its life cycle. Despite the importance of post-transcriptional regulation, key elements of these processes, namely RNA binding proteins (RBPs), are poorly characterize...
ORGANISM(S): Plasmodium falciparum 
2014-10-23 | E-GEOD-56329 | biostudies-arrayexpress
UnknownBruno protein contains an expanded RNA recognition motif.
Not available
S-EPMC4301712 | biostudies-literature
ProteomicsBruno 1 regulates cytoskeleton dynamics and a temporal splicing transition to promote myofibril assembly, growth and maturation in Drosophila flight muscle
Muscles undergo developmental transitions in gene expression and alternative splicing that are necessary to refine sarcomere structure and contractility. CUG-BP and ETR-3-like (CELF) family RNA binding proteins are important regulators of RNA processing during myogenesis that are misregulated in dis...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-03-08 | PXD043308 | Pride
Muscle development Drosophila Flight muscle Celf Bruno 1 
ProteomicsMakorin 1 controls embryonic patterning by alleviating Bruno-mediated repression of oskar translation
Makorins are an evolutionary conserved family of proteins that contain C3H-type zinc finger modules and a RING E3 ubiquitin ligase domain. Previous analysis indicated a maternal role for Makorin 1 (Mkrn1) in Drosophila embryonic patterning and germ cell specification, but the underlying mechanism ha...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-01-29 | PXD011802 | Pride
Polyadenylation Pole plasm Germ cell specification Drosophila Oogenesis Mkrn1 
UnknownBruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly in Drosophila flight muscles.
Not available
S-EPMC11081514 | biostudies-literature
TranscriptomicsRegulatory role of glycerol in Candida albicans biofilm formation
Biofilm formation on medically implanted devices by Candida albicans poses a significant clinical challenge. Here we compared biofilm-associated gene expression in two clinical C. albicans isolates, SC5314 and WO-1, to identify shared gene regulatory responses that may be functionally relevant. Amon...
ORGANISM(S): Candida albicans 
2013-04-12 | E-GEOD-45141 | biostudies-arrayexpress
UnknownPost-transcriptional regulation of <i>cyclin A</i> and <i>B</i> mRNAs by Bruno 1, Cup, and P-bodies.
Not available
S-EPMC12179632 | biostudies-literature
GenomicsDr. Bruno Paiva
Data Access Committee EGAC00001001679
EGAC00001001679 | EGA
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