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ProteomicsA proteomics-based assessment of inflammation signatures in endotoxemia
The circulating proteome offers insight into the stage and severity of the immune response. To characterise the release kinetics and cellular source of plasma protein changes, serial samples were obtained from healthy volunteers (n=10, 3 time-points) injected with low-dose endotoxin (LPS) and analys...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-11 | PXD021077 | Pride
Human Lps Aorta Dia Tmt Endotoxemia Plasma Mouse 
ProteomicsStructural and Functional Glycosylation of the Abdala COVID-19 Vaccine
Abdala is a COVID-19 vaccine produced in Pichia pastoris and is based on the receptor-binding domain (RBD) of the SARS-CoV-2 spike. Abdala is currently approved for use in multiple countries with clinical trials confirming its safety and efficacy in preventing severe illness and death. Although P. p...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058644 | Pride
Glycosylation Covid Sars Abdala 
ProteomicsAn N-glycan on the C2 domain of Jagged-1 is essential for Notch activation
Glycoproteomics determination of human jagged-1 glycan composition
ORGANISM(S): Homo sapiens (Human) 
2022-10-17 | PXD034133 | Pride
Glycoproteomics Jagged1 
ProteomicsAn N-glycan on the C2 domain of Jagged-1 is essential for Notch activation
Glycoproteomic determination of human Jagged-1 glycan composition
ORGANISM(S): Homo sapiens (Human) 
2023-06-28 | PXD034130 | Pride
293f Glyoproteomics Jagged-1 293s 
ProteomicsCross-linking mass spectrometry uncovers interactions between high-density lipoproteins and the SARS-CoV-2 spike glycoprotein
Multiple studies to date have shown that high-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and that the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the lifecycle of he...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041438 | Pride
Xl-ms Sasrs-cov Covid-19 Hdl 
ProteomicsCross-linking mass spectrometry uncovers interactions between high-density lipoproteins and the SARS-CoV-2 spike glycoprotein
Multiple studies to date have shown that high-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and that the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the lifecycle of he...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041831 | Pride
Covid-19 Plasma Xl-ms 
ProteomicsCross-linking mass spectrometry uncovers interactions between high-density lipoproteins and the SARS-CoV-2 spike glycoprotein
Multiple studies to date have shown that high-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and that the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the lifecycle of he...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD042625 | Pride
Hdl Spike Xlms. cov 
ProteomicsCross-linking mass spectrometry uncovers interactions between high-density lipoproteins and the SARS-CoV-2 spike glycoprotein
Multiple studies to date have shown that high-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and that the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the lifecycle of he...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036640 | Pride
Xlms Covid Spike Sars-cov-2 Hdl 
ProteomicsLoss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis
miR-33 is an intronic microRNA within the gene encoding the SREBP2 transcription factor. Like its host gene, miR-33 has been shown to be an important regulator of lipid metabolism. Inhibition of miR-33 has been shown to promote cholesterol efflux in macrophages by targeting the cholesterol transport...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD023471 | Pride
Mouse plasma 
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