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ProteomicsThe hTERT-RPE1 secretome after TLR3 stimulation
RPE cells perform a number of support functions in the inner eye including the secretion of signalling molecules and the maintenance of the immune privileged environment through communication with the immune system (Detrick and Hooks, 2010). Previous reports have demonstrated that RPE cells express ...
ORGANISM(S): Homo sapiens (Human) 
2020-06-16 | PXD019445 | Pride
Poly(i:c) Htert-rpe1 Human Secretome 
ProteomicsThe OPTN interactome using BioID
We use a proximity labelling-based proteomics strategy (BioID) to map the interactome of OPTN. OPTN was tagged N and C-terminally with BirA* in RPE1 cells and then, after labelling with biotin, streptavidin pull downs were performed to identify OPTN-proximal proteins.
ORGANISM(S): Homo sapiens (Human) 
2020-06-16 | PXD019386 | Pride
Bioid Optn 
ProteomicsPlasmodium falciparum PfMyoF with a Rab-like tail domain associates with perinuclear membranes and trafficking proteins
Members of the myosin superfamily are found in all eukaryotes, including Plasmodium falciparum, the parasite that causes the majority of severe malaria. The P. falciparum genome encodes six myosins, but apart from PfMyoA and B, these remain largely uncharacterised. Here, we characterise PfMyoF, a cl...
ORGANISM(S): Plasmodium (Paraplasmodium) 
2026-04-27 | PXD077305 | Pride
Malaria Myosin Ip-ms Trafficking 
ProteomicsThe MYO6 interactome using BioID
The intracellular function of myosin motors requires a number of adaptor molecules, which control cargo attachment, but also fine-tune motor activity in time and space. These motor-adaptor-cargo interactions are often weak, transient or highly regulated. To overcome these problems we use a proximity...
ORGANISM(S): Homo sapiens (Human) 
2018-02-27 | PXD008686 | Pride
Myo6 Bioid 
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