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ProteomicsThe OPTN interactome using BioID
We use a proximity labelling-based proteomics strategy (BioID) to map the interactome of OPTN. OPTN was tagged N and C-terminally with BirA* in RPE1 cells and then, after labelling with biotin, streptavidin pull downs were performed to identify OPTN-proximal proteins.
ORGANISM(S): Homo sapiens (Human) 
2020-06-16 | PXD019386 | Pride
Bioid Optn 
ProteomicsInvestigating Autophagy Disruption Induces Neurodegeneration in Glaucoma OPTN(E50K) Retinal Ganglion Cells
Retinal ganglion cells (RGCs) are the sole projection neurons that connect the eye with the brain, and the degeneration of these cells in diseases such as glaucoma results in vision loss or blindness. Similar to other neurons throughout the central nervous system, RGCs are postmitotic and therefore ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD033173 | Pride
Autophagy Human pluripotent stem cell Retinal ganglion cells 
GenomicsscRNAseq of FACS-isolated microglia from spinal cords of Optn KO mice
scRNAseq of FACS-isolated microglia from spinal cords of Optn KO mice
PRJNA704326 | ENA
GenomicsOPTN as a therapeutic target for acetaminophen-induced liver injury by activating mitophagy
OPTN as a therapeutic target for acetaminophen-induced liver injury by activating mitophagy
PRJNA802056 | ENA
ProteomicsPEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy
Peroxisome degradation, known as pexophagy, is essential for eliminating surplus and dysfunctional peroxisomes, with dysregulation linked to various diseases. Previous research revealed that ectopic expression of optineurin (OPTN), a versatile autophagy adaptor involved in multiple autophagic pathwa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-23 | PXD053489 | Pride
Pex14 Peroxisomes Pexophagy Ubiquitin Optineurin 
TranscriptomicsOPTN as a therapeutic target for acetaminophen-induced liver injury by activating mitophagy
Acetaminophen (APAP) is a leading cause of acute liver failure in Western countries result from the accumulation of damaged mitochondria. However, there is no related clinically useful therapeutic intervention. Optineurin (OPTN) is a multifunctional protein involved in autophagy, oxidative stress, a...
ORGANISM(S): Mus musculus 
2024-08-21 | GSE195753 | GEO
GenomicsDifferential gene expression and pathway analysis by RNA sequencing in human OPTN(E50K) retinal ganglion cells
Differential gene expression and pathway analysis by RNA sequencing in human OPTN(E50K) retinal ganglion cells
PRJNA605854 | ENA
GenomicsDifferential gene expression and pathway analysis by RNA sequencing in human OPTN(E50K) astrocytes
Differential gene expression and pathway analysis by RNA sequencing in human OPTN(E50K) astrocytes
PRJNA723860 | ENA
GenomicsscRNAseq of CD45 enriched cells from spinal cords of Optn floxed and KO mice
scRNAseq of CD45 enriched cells from spinal cords of Optn floxed and KO mice
PRJNA704318 | ENA
Genomics
The effect of optn in muscle atrophy
PRJNA1180983 | ENA
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