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ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 – CTAP discovery
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. CTAPs can arise from internal protein cleavage events during which the N-terminal fragme...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055814 | Pride
C-terminal amide Oxidative stress Ubiquitin ligase Fbxo31 
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. Profiling of active cullin-RING ubiquitin E3 ligases was performed in naive or FBXO31 kno...
ORGANISM(S): Homo sapiens (Human) 
2024-11-07 | PXD055518 | Pride
Ligase Cullin Fbxo31 Ring Scf Ubiquitin E3 
UnknownDesign and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications.
Not available
S-EPMC4027376 | biostudies-literature
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 - Interaction Proteomics of FBXO31 in HEK293T cells
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. Immunoprecipitation followed by MS (IP-MS) was performed on HA-tagged cDNA-expressed var...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055535 | Pride
Ap-ms Fbxo31 Ip-ms Oxidative stress Ubiquitin ligase 
UnknownElucidating the molecular determinants in the process of gastrin C-terminal pentapeptide amide end activating cholecystokinin 2 receptor by Gaussian accelerated molecular dynamics simulations.
Not available
S-EPMC9899899 | biostudies-literature
TranscriptomicsThe C-Terminal Domain of RNA Polymerase II is Modified by Site-Specific Methylation
The Carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) in mammals undergoes extensive post-translational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the transcriptional co-...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-27315 | biostudies-arrayexpress
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 – Expression Proteomics
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. FBXO31(D334N) is a dominant de novo mutation found among patients with cerebral palsy. T...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055818 | Pride
Tmt Ubiquitin ligase Fbxo31 
UnknownOn the importance of being amidated: Analysis of the role of the conserved C-terminal amide of amylin in amyloid formation and cytotoxicity.
Not available
S-EPMC11223093 | biostudies-literature
ProteomicsC-terminal glycosylation of type IX secretion system cargo proteins in Prevotella intermedia bearing both short and long secretion signals
Prevotella intermedia is a Gram-negative bacterium that is notably linked to periodontitis and acute necrotizing ulcerative gingivitis. P. intermedia is known to utilise the T9SS to secrete and anchor virulence factors to the cell surface, presumably via C-terminal modification of the cargo protein ...
ORGANISM(S): Prevotella intermedia ATCC 25611 = DSM 20706 
2025-05-07 | PXD057272 | Pride
Glycosylation Secretion signal Surface proteins Prevotella intermedia Alaninamide Mass spectrometry Protein secretion 
UnknownTracking the Amide I and αCOO- Terminal ν(C=O) Raman Bands in a Family of l-Glutamic Acid-Containing Peptide Fragments: A Raman and DFT Study.
Not available
S-EPMC8399447 | biostudies-literature
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