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TranscriptomicsDe novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function
Background: Despite significant improvements in short-term kidney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are poss...
ORGANISM(S): Homo sapiens 
2004-09-23 | E-GEOD-1743 | biostudies-arrayexpress
GenomicsTargeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma
Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma
PRJNA591204 | ENA
GenomicsRNA-seq of immortalized human podocytes treated with calcineurin inhibitors
RNA-seq of immortalized human podocytes treated with calcineurin inhibitors
PRJNA1413410 | ENA
GenomicsmRNA-sequencing data of Jurkat T cells with or without calcineurin inhibitors
mRNA-sequencing data of Jurkat T cells with or without calcineurin inhibitors
PRJNA769674 | ENA
UnknownCHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity and endocytosis.
Not available
S-EPMC6061875 | biostudies-literature
TranscriptomicsCalcineurin/NFAT signaling inhibits myeloid hematopoiesis in mice.
Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signaling can also mediate granulocyte and DC activation, but it is unknown whether NFAT influences their development from progenitors. Here w...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-29094 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analysis of TCR signaling with inhibitors
MAPK-Erk and calcium-Calcineurin pathways are major signaling pathways activated during TCR signal transduction. We investigated the effect of these signaling pathway with the use of selective inhibitors of Mek and calcineurin.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD000972 | Pride
Tcr signaling Calcineurin inhibitor Mek inhibitor 
UnknownTreatment with Glucocorticoids or Calcineurin Inhibitors in Primary FSGS.
Not available
S-EPMC4791818 | biostudies-literature
TranscriptomicsMechanisms and rescue strategies of Calcineurin inhibitor mediated tolerance abrogation
To ensure safety tolerance induction protocols are accompanied by conventional immunosuppressive drugs IS. But IS such as calcineurin inhibitors CNI can interfere with tolerance induction. We investigated the effect of an additional CNI treatment on anti-CD4 mAb-induced tolerance induction upon rat ...
ORGANISM(S): Rattus norvegicus 
2013-09-01 | E-GEOD-40454 | biostudies-arrayexpress
TranscriptomicsTargeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) represents the most common form of lymphoma. We could show that in DLBCL cell lines the transcription factor NFAT is constitutively activated and drives the survival of a DLBCL subset. Aim of the analysis was to identify NFAT target genes in a NFAT-dependent (HB...
ORGANISM(S): Homo sapiens 
2019-11-23 | GSE140882 | GEO
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