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ProteomicsNovel insights into quantitative proteomics from an innovative bottom-up Simple Light Isotope Metabolic (bSLIM) labeling data processing strategy
The Simple Light Isotope Metabolic labeling (SLIM-labeling) is an inovative method to quantify proteome variations based on an original in vivo labeling strategy. Heterotrophic cells grown on a U-[12C] sole source of carbon synthesize U-[12C]-amino acids which are incorporated into proteins giving r...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-15 | PXD021329 | Pride
Openms Data processing workflow Yeast In vivo metabolic labeling Light carbon isotope Quantitative proteomics 12c Knime 
ProteomicsTraining set - Novel insights into quantitative proteomics from an innovative bottom-up Simple Light Isotope Metabolic (bSLIM) labeling data processing strategy
The Simple Light Isotope Metabolic labeling (SLIM-labeling) is an inovative method to quantify proteome variations based on an original in vivo labeling strategy. Heterotrophic cells grown on a U-[12C] sole source of carbon synthesize U-[12C]-amino acids which are incorporated into proteins giving r...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-16 | PXD021502 | Pride
Openms Data processing workflow Yeast In vivo metabolic labeling Light carbon isotope Quantitative proteomics 12c Knime 
ProteomicsIn vivo dynamics of Iron Starvation Induced Proteins under variable iron supplementation regimes suggest an iron processing organelle in Phaeodactylum tricornutum.
The model pennate diatom Phaeodactylum tricornutum is able to assimilate a range of iron sources. It therefore provides a platform to study different mechanisms of iron processing concomitantly in the same cell. In this study we follow the localisation of three iron starvation induced proteins (ISIP...
ORGANISM(S): Phaeodactylum tricornutum 
2023-03-10 | PXD021172 | Pride
Iron starvation induced proteins Fluorescent proteins Diatoms Siderophores Iron Proteome Phaeodactylum tricornutum 
UnknownMolecular Mechanisms of <i>Acanthamoeba castellanii</i> Response to Different Sources of Oxidative Stress.
Not available
S-EPMC11812009 | biostudies-literature
UnknownExtending the Range of SLIM-Labeling Applications: From Human Cell Lines in Culture to Caenorhabditis elegans Whole-Organism Labeling.
Not available
S-EPMC9990122 | biostudies-literature
ProteomicsProteomic landscape of cholangiocarcinomas reveals 3 different subgroups according to their localization and the underlying non-tumor liver
Cholangiocarcinomas (CC) define a heterogeneous entity based upon their anatomic localization along the biliary tree and, for those developing in the liver (iCC), depending on the aspect of non tumoral liver (cirrhosis or not). Gene expression analysis of iCC revealed 2 main subgroups (inflammatory ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-11 | PXD010294 | Pride
Quantitative proteomics Cholangiocarcinoma 
UnknownOver-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.
Not available
S-EPMC10399536 | biostudies-literature
ProteomicsSIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism
Inborn errors of vitamin B12 metabolism (IECM) resulting from impaired methionine synthase (MS, encoded by MTR) activity cause severe cognitive and neurological deficits that are often unresponsive to conventional B12 supplementation. Using a brain-specific Mtr knockout mouse model, we identified th...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-06 | PXD071487 | Pride
Vitamin b12 deficiency Methionine synthase One-carbon metabolism Wnt signaling Inborn errors of cobalamin metabolism Sirt1  neurogenesis Energy metabolism 
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