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ProteomicsCaMKK2 Inactivation by cAMP-PKA Signaling and 14-3-3 Adaptor Proteins
The calcium-calmodulin (Ca2+-CaM) dependent protein kinase kinase-2 (CaMKK2) is activated by increases in intracellular Ca2+ and is a key regulator of cellular and wholebody energy metabolism. CaMKK2 inhibition protects against prostate cancer, hepatocellular carcinoma and metabolic derangements ind...
ORGANISM(S): Homo sapiens (Human) 
2020-11-06 | PXD020133 | Pride
Cyclic amp (camp) Calcium-calmodulin (ca2+-cam) dependent protein kinase kinase-2 (camkk2) Protein kinase a (pka) 14-3-3 adaptor proteins 
ProteomicsIndentification of CaMKK2-binding proteins in 293T cells
Indentification of CaMKK2-binding proteins under cystine starvation condition in 293T cells.
ORGANISM(S): Homo sapiens (Human) 
2021-07-24 | PXD027017 | Pride
293t cells Camkk2 
GenomicsCaMKK2 regulates mechanically-induced macrophage fate
CaMKK2 regulates mechanically-induced macrophage fate
PRJNA1143445 | ENA
ProteomicsMining gastric cancer cellular quantitative proteomics data to analyse the proteome change upon CAMKK2 inhibition
Gastric cancer is a global health concern. Molecular alterations in various signaling pathways have been implicated in the development and late-stage progression/metastasis of gastric cancer. Reports have suggested that Wnt signaling pathway might contribute to gastric carcinogenesis by stimulating ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-13 | PXD023423 | Pride
Sto-609 Data mining Camkk2 Mass spectrometry Proteomics Gastric cancer 
ProteomicsLiP-MS on CAMKK2 Purified from HEK293 cells treated with SGC-CAMKK2-1
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058369 | Pride
Chemical probe Lip-ms 
UnknownSGC-CAMKK2-1: A Chemical Probe for CAMKK2.
Not available
S-EPMC9856672 | biostudies-literature
TranscriptomicsCaMKK2 regulates mechanically-induced macrophage fate
Macrophages play crucial roles in immunity and tissue homeostasis, exhibiting diverse phenotypes influenced by their microenvironment. While matrix stiffness is recognized as a key regulator of macrophage fate, the underlying mechanism remains elusive. Here, we investigate primary bone marrow-derive...
ORGANISM(S): Mus musculus 
2025-04-30 | GSE273834 | GEO
GenomicsTPD52 Inhibits Aldosterone Synthesis Through Suppression of CAMKK2 Signaling
TPD52 Inhibits Aldosterone Synthesis Through Suppression of CAMKK2 Signaling
PRJNA1422777 | ENA
ProteomicsMining gastric cancer cellular quantitative phosphotyrosine proteomics data to analyse the signiling cascade regulated my CAMKK2 in gastric cancer
Gastric cancer is a global health concern. Tyrosine kinases (TKs) are important mediators of signaling cascades, which regulate diverse biological processes like growth, differentiation, metabolism, and apoptosis in response to external and internal stimuli. Molecular alterations in various signalin...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD032001 | Pride
Sto-609 Data mining Camkk2 Mass spectrometry Proteomics Stat3 Gastric cancer 
TranscriptomicsGene expression in WT and Camkk2 KO murine hematopoietic stem cells
To determine the function of Camkk2 in HSC we performed a microarray analysis on isolated KSL from WT and Camkk2 null mice. Using a threshold of 0.05 for statistical significance (p-value) and a log fold change of expression with absolute value of at least 0.6, 1831 differentially expressed genes (D...
ORGANISM(S): Mus musculus 
2018-02-13 | GSE95733 | GEO
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