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ProteomicsProteomics from Triple-Negative Breast Cancer from the MMTV-R26Met Model
We have developed the MMTV-R26Met mouse model, which exclusively generates TNBC and recapitulates key features of the human disease in an immunocompetent setting. In this study, we provide a proteomics characterization of MMTV-R26Met-derived tumors. This integrative approach reveals distinct tumor c...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-16 | PXD067482 | Pride
Triple-negative breast cancer Breast cancer mouse model Proteomic 
ProteomicsPhosphoproteome profiles of prostate cancer cell lines
Prostate cancer (PCa) is a major public health issue in industrialized countries, mainly because of patients’ relapse by castration-refractory disease after androgen ablation. PCa progresses through a series of clinical states characterized by the extent of the disease, the hormonal status (castrati...
ORGANISM(S): Homo sapiens (Human) 
2020-01-14 | PXD004992 | Pride
Human Lc-ms Prostate cancer 
ProteomicsIdentification of O-GlcNAcylated proteins and mapping of O-GlcNAc sites using Click Chemistry following extensive fractionation of extracted proteins
The O-N-acetyl-β-D-glucosaminylation, termed O-GlcNAcylation, is an atypical glycosylation corresponding to the transfer of a unique saccharide, the N-acetyl-β-D-glucosamine, on the hydroxyl group of serine and threonine amino acids of nuclear, cytosolic and mitochondrial proteins. Because of its dy...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-21 | PXD004860 | Pride
Muscle Mouse O-glcnacylation Lc_msms Sites mapping Post-translational modifications C2c12 muscle cells 
ProteomicsInteractome of the Escherichia coli nitrate reductase respiratory complex, NarGHI, under various metabolic conditions
Cellular respiration is a fundamental process undergone within energy-transducing membranes through the redox activity of multimeric protein assemblies, so-called respiratory complexes. In most cases, electron transport is ensured by lipophilic molecules, quinones, serving as electron shuttles. This...
ORGANISM(S): Escherichia coli 
2019-10-07 | PXD012320 | Pride
Narghi Escherichia coli Nitrate respiration Label-free Interactome 
ProteomicsProteomics profiles of prostate cancer cell lines
Prostate cancer (PCa) is a major public health issue in industrialized countries, mainly because of patients’ relapse by castration-refractory disease after androgen ablation. PCa progresses through a series of clinical states characterized by the extent of the disease, the hormonal status (castrati...
ORGANISM(S): Homo sapiens (Human) 
2020-01-14 | PXD004970 | Pride
Human Lc-msms Proteomics Prostate cancer Cell lines 
ProteomicsInteractomics of the RLTPR protein explain its essential role for costimulation via CD28
The RLTPR cytosolic protein has an essential role in CD28 costimulation but its mode of action and importance in human T cells remain elusive. Here, using mass spectrometry we showed that CD28, RLTPR and the CARMA1 cytosolic adaptor physically associate in mouse T cells. Although RLTPR is thought to...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-27 | PXD003870 | Pride
Mouse Rltpr Lc-ms/ms 
ProteomicsModulation of Serpin family levels detected by proteomics to monitor colorectal adenoma to carcinoma progression
Colorectal cancer (CRC) remains a major cause of cancer related-death in developed countries. The risk of death is correlated with the stage of CRC determined at the primary diagnosis and early diagnosis is associated with enhanced survival rate. Consequently, there is an interest in using proteomic...
ORGANISM(S): Homo sapiens (Human) 
2016-08-26 | PXD001794 | Pride
Colorectal cancer Mass spectrometry Elisa Biomarker Itraq 
ProteomicsThe tumor suppressor SCRIB is a negative modulator of the Wnt/-catenin signaling (part 1)
Epithelial tissues are highly organized structures that rely on cell polarity pathways driven by membrane receptors and scaffolding proteins. SCRIBBLE is a cytoplasmic scaffold present at cell-cell junctions in polarized cells that contains LRR and PDZ domains as its paralogue LANO, a member of the ...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD013647 | Pride
Scrib  lrrc1  proteomics analysis 
ProteomicsThe tumor suppressor SCRIB is a negative modulator of the Wnt/-catenin signaling (part 2)
Epithelial tissues are highly organized structures that rely on cell polarity pathways driven by membrane receptors and scaffolding proteins. SCRIBBLE is a cytoplasmic scaffold present at cell-cell junctions in polarized cells that contains LRR and PDZ domains. The current interactome of SCRIB and L...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD013636 | Pride
Scrib  mg132  proteomics analysis 
ProteomicsDissecting the antibacterial activity of Oxadiazolone-core derivatives against Mycobacterium abscessus
Mycobacterium abscessus is nowadays under the spotlight of the scientific community. This pathogenic mycobacteria is indeed responsible for a wide spectrum of infections involving mostly pulmonary infections in patients with cystic fibrosis. M. abscessus is intrinsically resistant to a broad range o...
ORGANISM(S): Mycobacterium abscessus 
2020-08-14 | PXD015680 | Pride
Drug susceptibility  intracellular activity  activity based-protein profiling  proteomic analysis 
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