Sort   by:  
 Page size 
MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
ProteomicsEssential role of NLRC5 in cancer immune surveillance and cancer immunoediting
Background/Objectives: Downregulation of NLRC5, the transcriptional activator of MHC class-I, results in tumor immune evasion via escape from CD8+ T cell-mediated tumor control. As NLRC5 deficiency does not abrogate CD8+ T cell development, we investigated whether NLRC5-dependent antitumor immune me...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-19 | PXD060523 | Pride
Cancer immune surveillance  cancer immunoediting  nlrc5  mhc class-i  3-methylcholanthrene  cytolytic t lymphocyte  granzyme 
MetabolomicsNon-targeted metabolomics reveals diagnostic biomarker in the plasma of patients with lung cancer

Lung cancer are malignant tumors with high incidence and mortality rates, and a 5-year survival rate that depends on the stage at the time of diagnosis. Screening methods for lung cancer are becoming increasingly diverse, but existing approaches lack sensitivity or specificity for early lesions, ...

2025-09-13 | MTBLS12985 | MetaboLights
TranscriptomicsTenascin-C Protects Cancer Stem-Like Cells from Immune Surveillance
Precociously disseminated cancer cells may seed quiescent sites of future metastasis if they can protect themselves from immune surveillance. However, there is little knowledge about how such sites might be achieved. Here we present evidence that prostate cancer stem-like cells (CSC) can be found in...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-65502 | biostudies-arrayexpress
GenomicsCisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in colorectal cancer
Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in colorectal cancer
PRJEB77057 | ENA
ProteomicsAntagonistic roles of histone 3 lysine methyltransferases dictate tumor immune surveillance
Histone H3 lysine 36 (H3K36) methyltransferases are frequently mutated in cancer, but their functional roles remain unclear. Using functional genomics approaches within KRAS-driven lung cancer models, we show that NSD2, SETD2, and EZH2 work in concert to regulate expression of endogenous retroviral ...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-22 | PXD069619 | Pride
Nsd2 Epigenetic vulnerability Immune surveillance Chromatin regulation Ervs Kras lung cancer H3k36 methylation Ezh2 Setd2 H3k36m 
ProteomicsUSP5 Stabilizes YTHDF1 to Control Cancer Immune Surveillance through mTORC1-mediated Phosphorylation
The N6-methyladenosine (m6A) binding protein YTHDF1 emerges as a frequently upregulated oncogene across various cancer types. Its depletion significantly improves the efficacy of cancer immune checkpoint blockade (ICB) treatment. A comprehensive understanding of the molecular mechanisms governing YT...
ORGANISM(S): Homo Sapiens 
2024-11-14 | PXD057917 |
MetabolomicsLimited vertical transmission but profound immune dysregulation at the maternal-fetal interface after SARS-CoV-2 infection

The endemic of SARS-CoV-2 underscores the imperative to elucidate its effects on pregnancy, particularly regarding the potential for vertical transmission and its influence on the early maternal-fetal interface, which remain insufficiently defined. To address this, we performed an extensive cohor...

2026-03-05 | MTBLS13103 | MetaboLights
GenomicsTumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer
Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer
PRJNA945465 | ENA
Sort   by:  
 Page size