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ProteomicsLOPIT-DC subcellular map of U-2 OS cells
Generation of a high-resolution subcellular localisation map for the proteome of the human cancer cell line U-2 OS, using the newly developed LOPIT-DC method. Comparison of the results generated using LOPIT-DC with data generated using the well-established hyperLOPIT method and data mining regarding...
ORGANISM(S): Homo sapiens (Human) 
2019-01-23 | PXD011254 | Pride
Lopit-dc Hyperlopit Cancer subcellular map Spatial proteomics 
ProteomicsMapping the spatial proteome of metastatic cells in colorectal cancer
Here, we aimed to study metastasis mechanisms using spatial proteomics applied to the KM12 cell model of metastasis. KM12 cells were metabolically labelled using SILAC. SILAC has been successfully used for the analysis of proteome turnover and for the identification of changes in proteome localizati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-23 | MSV000088431 | MassIVE
ProteomicsLOPIT-DC subcellular map of U-2 OS cells
Generation of a high-resolution subcellular localisation map for the proteome of the human cancer cell line U-2 OS, using the newly developed LOPIT-DC method. Comparison of the results generated using LOPIT-DC with data generated using the well-established hyperLOPIT method and data mining regarding...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-23 | MSV000088434 | MassIVE
ProteomicsMapping the spatial proteome of metastatic cells in colorectal cancer
Here, we aimed to study metastasis mechanisms using spatial proteomics applied to the KM12 cell model of metastasis. KM12 cells were metabolically labelled using SILAC. SILAC has been successfully used for the analysis of proteome turnover and for the identification of changes in proteome localizati...
ORGANISM(S): Homo sapiens (Human) 
2017-09-11 | PXD006656 | Pride
Subcellular fraction Colorectal cancer Silac Lc-ms/ms 
UnknownA subcellular map of the human kinome.
Not available
S-EPMC8175086 | biostudies-literature
UnknownHigh-resolution imaging mass cytometry to map subcellular structures.
Not available
S-EPMC12695663 | biostudies-literature
MetabolomicsGolgi-IP, a tool for multimodal analysis of Golgi molecular content
The Golgi is a membrane-bound organelle that is essential for protein and lipid biosynthesis. It represents a central trafficking hub that sorts proteins and lipids to various destinations or for secretion from the cell. The Golgi has emerged as a docking platform for cellular signaling pathways inc...
2023-06-27 | MTBLS6511 | MetaboLights
ProteomicsHMGB1 interactome in prostate and ovarian cancer cells
This study reports the interactome of HMGB1 in prostate and ovarian cancer cells, which includes a variety of proteins involved in diverse cellular processes. Subcellular fractionation is used to map the distribution of interacting proteins. In the nucleus, HMGB1 interacts directly with NuRD complex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026258 | Pride
Septin Thoc complex Prostate cancer Ovarian cancer Ribosome biogenesis Hmgb1 Skov-1 Nurd complex Rab11 Pc3 
TranscriptomicsNovel Roles fro ERK5 and Cofiin as Critical Mediators Linking Estrogen Receptor α-Driven Transcription, Actin Reorganization and Invasiveness in Breast cancer
Cancer cell motility and invasiveness are fundamental characteristics of the malignant phenotype and are regulated through diverse signaling networks involving kinases and transcription factors. In this study, we identify a nuclear hormone receptor (ERα)-protein kinase (ERK5)-cofilin (CFL1) network ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-53394 | biostudies-arrayexpress
TranscriptomicsExpression data from TOP-GFP sorted colon cancer cells
Colon cancers typically contain tumor cell populations with differential WNT signaling activity. Colon cancer cells with high WNT-activity have been attributed increase tumorigenic potential and stem cell characteristics. We extracted tumor cells with differential WNT activity using fluorescent repo...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-32408 | biostudies-arrayexpress
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