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TranscriptomicsEffects of CBD on the glioma stem cell molecular signature
Primary glioma stem cells cultured as neurospheres in NBL media with growth factors were subjected to treatment with the non-toxic, non-psychoactive cannabis compound cannabidiol (CBD). Control and CBD- treated cultures were used to generate RNA used to hybridize on Affymetrix DNA arrays Fluorescenc...
ORGANISM(S): Homo sapiens 
2015-04-17 | E-GEOD-57978 | biostudies-arrayexpress
TranscriptomicsEffects of (-)-cannabidiol on human sebocytes
In the current study, we aimed at exploring the effects of the major non-psychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland functions. We found that CBD behaved as a highly effective anti-acne agent, targeting all the three key, sebocyte-specific steps ...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-57571 | biostudies-arrayexpress
ProteomicsProteome-wide profiling using sample multiplexing of a human neuroblastoma SH-SY5Y cell line treated with cannabidiol (CBD) and tetrahydrocannabinol (THC)
Cannabis has been used throughout history for medicinal and recreational purposes. The most notable cannabinoids derived from these plants are cannabidiol (CBD) and tetrahydrocannabinol (THC). Although well studied for their therapeutic effects, and highly debated concerning their recreational use, ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD038121 | Pride
Tmtpro Endoplasmic reticulum stress Mitochondrial dysfunction Cannabidiol Unfolded protein response Delta-9-tetrahydrocannabinol Rts 
ProteomicsIdentification of Cannabidiol interactome in K562 cells
Cannabidiol (CBD) showed antiproliferative activity and induction of apoptosis in chronic myelogenous leukaemia cancer cells (K562 cells). A consolidated DARTS (Drug Affinity Response Target Stability) and t-LIP-MRM (targeted- Limited Proteolysis-Multiple Reaction Monitoring Mass spectrometry) platf...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD036650 | Pride
Cbd  k562 cells  top2a  darts  t-lip-mrm  chemoproteomics  mass spectrometry 
TranscriptomicsMicroarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
Cannabinoids are known to exert immunosuppressive activities. However, the mechanisms which contribute to these effects are unknown. Using lipopolysaccharide (LPS) to activate BV-2 microglial cells, we examined how Δ9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, and can...
ORGANISM(S): Mus musculus 
2015-07-09 | E-GEOD-70689 | biostudies-arrayexpress
ProteomicsAnti-Ferroptotic Effect of Cannabidiol in Human Skin Keratinocytes Characterized by Data-Independent Acquisition-Based Proteomics
SWATH-MS data for human keratinocytes (HaCaT cell line), sample 010-012 indicates HaCaT cells with no treatment, sample 013-015 indicates HaCaT cells induced by erastin, sample 0016-018 indicates HaCaT cells treated by erastin and CBD. For more detailed information, please contact Dr.Chang Liu (hich...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-18 | MSV000094348 | MassIVE
ProteomicsShotgun proteomic elucidation of Synergistic mechanisms of Cannabidiol and SN-38 in the MCF7 cells
We evaluted the synergyistic interactions of cannabidiol (CBD) with standard chemotherapeutic agents such as Docetaxel (DOC), doxorubicin (DOX), paclitaxel (PTX), vinorelbine (VIN), and 7-Ethyl-10-hydroxycamptothecin (SN38) in MCf7 cells ultising different synergy metrics. Then we explored the syner...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026587 | Pride
Breast cancer Proteomics Mcf7 Synergy Cannabidiol Sn-38 Cbd 7-ethyl-10-hydroxycamptothecin 
GenomicsElucidating The Role Of ∆9-Tetrahydrocannabinol (Thc) And Cannabidiol (Cbd) In Developmental Toxicity
Elucidating The Role Of ∆9-Tetrahydrocannabinol (Thc) And Cannabidiol (Cbd) In Developmental Toxicity
PRJNA688931 | ENA
GenomicsElucidating the transcriptomic response of adult hypothalamic neuron cells to cannabidiol (CBD) exposure
Elucidating the transcriptomic response of adult hypothalamic neuron cells to cannabidiol (CBD) exposure
PRJNA1126277 | ENA
TranscriptomicsElucidating the transcriptomic response of adult hypothalamic neuron cells to cannabidiol (CBD) exposure
Cannabidiol (CBD) actions in the brain are largely complex and not fully understood. One important brain structure that is a target for CBD, and for which health-beneficial CBD consequences can be seen is the hypothalamus. Given the fundamental role of gene expression in the hypothalamus's regulator...
ORGANISM(S): Mus musculus 
2024-08-01 | GSE270378 | GEO
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