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MetabolomicsEffects of MeJA on Arabidopsis metabolome under endogenous JA deficiency
Jasmonates (JAs) play important roles in plant growth, development and defense. Comprehensive metabolomics profiling of plants under JA treatment provides insights into the interaction and regulation network of plant hormones. Here we applied high resolution mass spectrometry based metabolomics appr...
2017-10-23 | MTBLS375 | MetaboLights
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsFunctional insights into protein acetylation in the hyperthermophilic archaeon Sulfolobus islandicus
Proteins undergo acetylation at the Nε-amino group of lysine residues and the Nα-amino group of the N-terminus in Archaea as in Bacteria and Eukarya. However, the extent, pattern and roles of the modifications in Archaea remain poorly understood. Here we report the proteomic analyses of a wild-type ...
ORGANISM(S): Sulfolobus islandicus REY15A 
2019-06-12 | PXD012246 | Pride
Quantitative proteomics Protein acetylome Gene deletion Mutant phenotype N-terminal acetyltransferase Protein lysine acetyltransferase 
ProteomicsProtein modification by a eukaryotic-like ubiquitin-related modifier in the hyperthermophilic archaeon Saccharolobus islandicus
Three independent analyses of Urm1 conjugation sites in the proteome of S. islandicus urm1 H81R strain were conducted. The data were analyzed using MaxQuant (v.1.6.15.0), and modified peptides were identified using a stringent standard.
ORGANISM(S): Sulfolobus islandicus REY15A 
2025-08-21 | PXD057602 | Pride
Saccharolobus islandicus Knockdown Urm1 Substrate 
UnknownElectroacupuncture potentiates peripheral CB2 receptor-inhibited chronic pain in a mouse model of knee osteoarthritis.
Not available
S-EPMC6231462 | biostudies-literature
ProteomicsPPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To ma...
ORGANISM(S): Homo Sapiens 
2023-02-21 | PXD040301 |
ProteomicsGel-based LC-MSMS, the interactome of XAF1 in 293T cells
We utilized mass spectrometry to analyze the interacting proteins of XAF1 in 293T cells.
ORGANISM(S): Homo Sapiens 
2023-03-22 | PXD041021 |
ProteomicsTomato SlLYK4 Phosphorylation LC-MS/MS
To identify the key phosphorylation residues of SlLYK4, we performed liquid chromatography-tandem mass spectrometry (LC-MS/MS)in vitro kinase assays with liquid of GST-SlLYK4 and MBP-SlLYK13CD or MBP (mock) after in vitro kinase assays. And then SlLYK4-FLAG was transiently expressed in tomato hairy ...
ORGANISM(S): Solanum Lycopersicum 
2024-08-29 | PXD055434 |
ProteomicsHydrogen sulfide mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small-cell lung cancer
Ferroptosis, a novel form of regulated cell death triggered by the iron-dependent peroxidation of phospholipids, offers promising penitential for cancer therapy. Hydrogen sulfide (H2S), an endogenous metabolite of the transsulfuration pathway, has been implicated in ferroptosis. However, the precise...
ORGANISM(S): Homo Sapiens 
2023-12-04 | PXD047493 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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