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ProteomicsAn immunoproteomic approach to characterize the CAR interactome and signalosome
Adoptive transfer of chimeric antigen receptor (CAR)-T cells is expected to become the first line of treatment for multiple malignancies, following the enormous success of anti-CD19 therapies. However, their mechanism of action is not fully understood, and clear guidelines for the design of safe and...
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD007085 | Pride
Interactome Chimeric antigen receptors Tonic signaling 
ProteomicsCoxsackievirus Adenovirus Receptor co-ordinates pro-inflammatory responses in the lung epithelium
Airway inflammation and remodelling are key pathophysiologic features process in many respiratory conditions such as asthma. An intact epithelial cell layer is crucial to maintain lung homeostasis, and this depends on intercellular adhesion. The Coxsackievirus Adenovirus Receptor (CAR) is highly exp...
ORGANISM(S): Homo sapiens (Human) 
2022-09-20 | PXD029237 | Pride
Bioid 16hbe human bronchial epithelial cells Car interactome 
ProteomicsAn immunoproteomic approach to characterize the CAR interactome and signalosome
Adoptive transfer of chimeric antigen receptor (CAR)-T cells is expected to become the first line of treatment for multiple malignancies, following the enormous success of anti-CD19 therapies. However, their mechanism of action is not fully understood, and clear guidelines for the design of safe and...
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD007086 | Pride
Phosphoproteomics Chimeric antigen receptors Tonic signaling 
UnknownAn immunoproteomic approach to characterize the CAR interactome and signalosome.
Not available
S-EPMC6506216 | biostudies-literature
ProteomicsCD99-mediated immunological synapse formation potentiates CAR-T cell function
Cross-talks between actin and microtubules underly various cellular processes. Using immune synapse model and via cytoskeleton dynamics analyses, here, we demonstrate that CD99 is critical for the actin and microtubule cross-talks and the coordinated reorganization, mediating their physical linkage ...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-18 | PXD039955 | Pride
Immunology Cd99 
ProteomicsMulti-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells
Proximity labeling proteomics (PLP) strategies are powerful approaches to yield snapshots of protein neighborhoods. Here, we describe a multi-scale PLP method with adjustable resolution using a commercially available photosensitizer, Eosin Y, which upon visible light illumination, activates differen...
ORGANISM(S): Homo sapiens (Human) Acyrthosiphon pisum (Pea aphid) 
2025-02-17 | PXD051348 | Pride
Chimeric antigen receptor (car) t cells Epidermal growth factor receptor Proximity labeling Photocatalysis Bispecific t cell engager 
ProteomicsIdentification of myelin basic protein interactome using TurboID proximity labeling proteomics
The protein environment of myelin basic protein (MBP), its uncharged form, and cyclindependent kinase inhibitor 1 (p21Cip1) were analyzed using two different approaches to identify protein partners thereof. The first one was a state-of-the-art enzymatic approach (TurboID), which utilizes an engineer...
ORGANISM(S): Homo sapiens (Human) 
2023-01-25 | PXD039467 | Pride
Proximity labeling proteomics Multiple sclerosis Immunoprecipitation Myelin basic protein Membrane 
ProteomicsmTOR inhibition via Rapamycin treatment partially reverts the deficit in energy metabolism caused by FH loss in RPE cells
To obtain insight into the molecular mechanism of FH intracellular function in hTERT-RPE1 cells, we analyzed the interactome of FH via its immunoprecipitation followed by MS-based analysis. We found that FH interacts with essential components of the ubiquitin-proteasomal pathway (UPS) as well as wit...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD029408 | Pride
Ap-proteomics Amd Interactome Complement factor h Mtor 
TranscriptomicsTranscriptional perturbations caused by tumor virus proteins
Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual genomic variations. Genome sequencing efforts ha...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38467 | biostudies-arrayexpress
GenomicsT cell landscape definition by multi-omics identifies galectin-9 as novel immunotherapy target in chronic lymphocytic leukemia (CLL)
Failure of immunotherapy after applying checkpoint inhibitors or CAR-T cells is linked to T cell exhaustion. Here, we explored the T cell landscape in chronic lymphocytic leukemia (CLL) by single-cell omics analyses of blood, bone marrow and lymph node samples of patients and spleen samples of a CLL...
EGAS00001006864 | EGA
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