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ProteomicsVMAT2 dysfunction impairs vesicular dopamine sequestration, driving oxidation and α-synuclein pathology in DJ-1-linked Parkinson’s disease neurons
Parkinson’s disease (PD) is characterized by the selective degeneration of dopaminergic neurons in the substantia nigra, yet its underlying molecular mechanism remains unclear. Excessive dopamine oxidation is a pathological hallmark observed in various forms of PD. Mutations in PD-associated genes, ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-07 | PXD066098 | Pride
Synaptic vesicles Vmat2 Atp Dopamine oxidation Clathrin Dj-1 Parkinson’s disease 
ProteomicsProteomics of human iPSC derived dopaminergic neurons with a Parkinson's disease linked PARK7/DJ-1 mutation
Parkinson’s disease (PD) is characterized by α-synuclein accumulation and dopaminergic neuron degeneration, with dopamine (DA) oxidation emerging as a key pathological driver. However, the mechanisms underlying this neurotoxic process remain unclear. Using PD patient-derived and CRISPR-engineered iP...
ORGANISM(S): Homo sapiens (Human) 
2026-01-07 | PXD069663 | Pride
Vmat2 Dj-1 Parkinson’s disease Dopaminergic neurons Park7 Ipsc derived neurons 
ProteomicsSecretome profiling of iPSC-derived microglia from β-propeller protein-associated neurodegeneration patients
Microglia are the brain’s resident immune cells, essential for homeostasis and implicated in common neurodegenerative diseases like Alzheimer’s and Parkinson’s disease (PD), where their early activation and sustained inflammatory mediator release precede neuronal loss. By contrast, their contributio...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD071930 | Pride
Bpan Microglia Hispecs Secretome 
ProteomicsBN-PAGE analysis of DJ-1 KO dopaminergic neurons
We subjected digitonin-soluble lysates of DJ-1 KO and isogenic control neurons to non-denaturing blue-native PAGE (BN-PAGE) to visualize and separate multi-subunit protein complexes associated with DJ-1.
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD069553 | Pride
Dopaminergic neurons Dj-1 Bn-page 
UnknownMental health and psychosocial impact of the COVID-19 pandemic and social distancing measures among young adults in Bogota, Colombia.
Not available
S-EPMC9807414 | biostudies-literature
UnknownPatient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration.
Not available
S-EPMC12710160 | biostudies-literature
UnknownThe development and implementation of a low-cost mechanical ventilator in a low-middle-income country during the COVID-19 pandemic: The Unisabana-HERONS.
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S-EPMC11096896 | biostudies-literature
UnknownOutcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis.
Not available
S-EPMC10278789 | biostudies-literature
UnknownOngoing declines for the world's amphibians in the face of emerging threats.
Not available
S-EPMC10567568 | biostudies-literature
UnknownColombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery - a prospective cohort study.
Not available
S-EPMC11382124 | biostudies-literature
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