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ProteomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs
Embryonic stem cells (ESCs) exhibit gene expression heterogeneity of key pluripotency factors (e.g. Nanog), suggesting functional relevance. To systematically identify potential regulators of transcriptional variability, we integrated single-cell RNA-seq (scRNA-seq) with ChIP-seq datasets in ESCs. O...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-06 | PXD071600 | Pride
Mesc  nap1l1  dppa3  transcriptional variability  pluripotency 
MetabolomicsPlasmid-encoded toxin defence mediates mutualistic microbial interactions

Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms while enabling the transfer of a diverse array of accessory functions. However, their precise impact on microbial community compo...

2023-08-10 | MTBLS7248 | MetaboLights
ProteomicsespL deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we show that EspL, a protein of 115 amino acids, is essential for mediating E...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-12-10 | PXD010929 | Pride
Mycobacterium Virulence Tuberculosis Espl 
ProteomicsespB deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we investigate the effect of espB on the secretion of ESX-1 components and ot...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2021-09-24 | PXD011475 | Pride
Esx-1 Espb Mycobacterium tuberculosis 
UnknownIndividual environmental niches in mobile organisms.
Not available
S-EPMC8316569 | biostudies-literature
UnknownBEAM/ATG or cyclophosphamide/ATG as conditioning regimen in autologous haemopoietic stem cell transplantation for multiple sclerosis: a retrospective analysis of the EBMT autoimmune diseases working party.
Not available
S-EPMC12672362 | biostudies-literature
MetabolomicsPlant species richness elicits changes in the metabolome of grassland species via soil biotic legacy
Species-rich plant communities can induce unique soil biotic legacy effects through changing the abundance and composition of soil biota. These soil legacy effects can cause feedbacks to influence plant performance. In addition, soil biota can induce (defensive) secondary metabolites in shoots ...
2019-05-30 | MTBLS544 | MetaboLights
UnknownTherapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.
Not available
S-EPMC5310766 | biostudies-literature
UnknownDevelopment of an adaptive clinical web-based prediction tool for kidney replacement therapy in children with chronic kidney disease.
Not available
S-EPMC10592093 | biostudies-literature
UnknownBaseline predictors for one-year visual outcomes with ranibizumab or bevacizumab for neovascular age-related macular degeneration.
Not available
S-EPMC3536921 | biostudies-literature
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