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UnknownChronic ethanol-mediated hepatocyte apoptosis links to decreased TET1 and 5-hydroxymethylcytosine formation.
Not available
S-EPMC6338639 | biostudies-literature
UnknownFirst-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors.
Not available
S-EPMC5562433 | biostudies-literature
ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
ProteomicsespL deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we show that EspL, a protein of 115 amino acids, is essential for mediating E...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-12-10 | PXD010929 | Pride
Mycobacterium Virulence Tuberculosis Espl 
ProteomicsespB deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we investigate the effect of espB on the secretion of ESX-1 components and ot...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2021-09-24 | PXD011475 | Pride
Esx-1 Espb Mycobacterium tuberculosis 
UnknownChallenges and Opportunities in Developing an Oncology Clinical Trial Network in the United States Veterans Affairs Health Care System: The VA STARPORT Experience.
Not available
S-EPMC11353739 | biostudies-literature
UnknownPhase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma.
Not available
S-EPMC5321073 | biostudies-literature
UnknownIntegrating a Parenting Assessment into Practice: Pediatric Providers' Time and Perspectives.
Not available
S-EPMC11420254 | biostudies-literature
UnknownRandomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.
Not available
S-EPMC5478045 | biostudies-literature
UnknownThe taste response to ammonia in Drosophila.
Not available
S-EPMC5338342 | biostudies-literature
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