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GenomicsSplicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 lysine 36
Several lines of recent evidence support a role for chromatin in splicing regulation. Here we show that splicing can also contribute to histone modification, which implies a bidirectional communication between epigenetics and RNA processing. Genome-wide analysis of histone methylation in human cell ...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30902 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation profiling of human HeLa cells after immunoprecipitation of ptb65 associated mRNAs
PTB is multifunctional RNA binding protein reported to be involved in splicing, 3' -end processing, stability and translational regulation. Sample preparation methods (Gama-Carvalho et al, 2006, submitted); Suspension HeLa cells were grown in DMEM, 10% FCS, Pen/Strep and split 1:2 the day before har...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6021 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of HeLa cells after immunoprecipitation of U2AF65 associated mRNAs
U2AF65 is an essential splicing factor involved in the 3'splice site recognition dureing the first steps of spliceosome assembly. In addition, this protein has nucleocytoplasmic shuttling activity and the Drosophila homologue has been implicated in mRNA export. We have used microarray hybridization ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6022 | biostudies-arrayexpress
UnknownGenetic modulation of RNA splicing rescues BRCA2 function in mutant cells.
Not available
S-EPMC11707380 | biostudies-literature
UnknownWhole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy.
Not available
S-EPMC5552324 | biostudies-literature
ProteomicsSpliceosome specifically associates with CTD phospho-serine 5 isoform of RNA polymerase II to promote co-transcriptional splicing
Co-transcriptional splicing of introns is a defining feature of eukaryotic gene expression. We show that the mammalian spliceosome specifically associates with the S5P CTD isoform of RNA polymerase II (Pol II) as it elongates across spliced exons of protein coding genes, both in human Hela and murin...
ORGANISM(S): Homo sapiens (Human) 
2018-10-05 | PXD008197 | Pride
Net-seq Transcription Spliceosome Splicing Ctd 
UnknownExpression Profiling in Ovarian Cancer Reveals Coordinated Regulation of BRCA1/2 and Homologous Recombination Genes.
Not available
S-EPMC8868827 | biostudies-literature
UnknownComprehensive Genomic Profiling of Cell-Free Circulating Tumor DNA Detects Response to Ribociclib Plus Letrozole in a Patient with Metastatic Breast Cancer.
Not available
S-EPMC9775495 | biostudies-literature
TranscriptomicsTbrucei_H1_RNAi
Our goal was to determine if histone H1 is involved in transcription regulation. RNA interference was used to deplete histone H1 from bloodstream form T. brucei in culture. Total RNA was extracted and RNAseq was used to compare the expression profile of H1 depleted clones and parental cell-line.
ORGANISM(S): Trypanosoma brucei brucei 
2014-07-10 | E-MTAB-1715 | biostudies-arrayexpress
UnknownYellow fever transmission in non-human primates, Bahia, Northeastern Brazil.
Not available
S-EPMC7418952 | biostudies-literature
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