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TranscriptomicsRestoration and reinforcement of acclimatizing responses during the adaptation of an unfit, metabolically engineered strain
Organisms cope with physiological stressors through acclimatizing mechanisms in the short-term, and through adaptive mechanisms over evolutionary timescales. Whereas the former offer a consistent and largely predictable buffer against stressors, myriad paths of adaptation are often possible. Our wor...
ORGANISM(S): Methylobacterium extorquens AM1 
2012-11-08 | E-GEOD-42116 | biostudies-arrayexpress
TranscriptomicsDefining the microglia transcriptome during disease progression in ALS transgenic mice
Purpose: We purified spinal cord microglia utilizing percoll gradients and magnetic beads, followed by transcriptome profiling (RNA-seq) to define microglia expression profiles against other neural, immune cell-types. We next observed how the microglial transcriptomes change during activation in the...
ORGANISM(S): Mus musculus 
2013-07-15 | E-GEOD-43366 | biostudies-arrayexpress
ProteomicsAkt phosphorylates insulin receptor substrate (IRS) to limit PI3K-mediated PI(3,4,5)P3 synthesis
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. Here, we show that Akt itself engages negative feedback by phosphorylating insulin receptor substrate (IRS) 1 and 2 on a number of residues. Mechanistic...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-14 | PXD023441 | Pride
Irs1 Signal transduction Pi3k Phosphorylation Akt Irs2 
UnknownHigh-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial.
Not available
S-EPMC10765403 | biostudies-literature
UnknownAntigen presentation by B cells enables epitope spreading across an MHC barrier.
Not available
S-EPMC10618542 | biostudies-literature
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