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MetabolomicsMass Spectrometry-Based Metabolic Fingerprinting Contributes to Unveil the Role of RSUME in Renal Cell Carcinoma Cell Metabolism
Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with 50-80% patients exhibiting mutations in the von Hippel-Lindau (VHL) gene. RSUME (RWD domain (termed after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)...
2021-10-06 | MTBLS1935 | MetaboLights
UnknownSerendipitous Enhancement of the Dimensionality in Diketopyrrolopyrroles through O-Substitution.
Not available
S-EPMC9999410 | biostudies-literature
ProteomicsO-GlcNAcase activity is necessary for the molecular signature of the Glioblastoma secretome
Glioblastoma (GBM) is a grade IV glioma highly aggressive and refractory to the therapeutic approaches currently in use nowadays. Although sugar metabolism through the hexosamine biosynthetic pathway (HBP) plays a key role in tumor aggressiveness and progression in different types of cancer, whether...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019496 | Pride
Glioblastoma secretome Lcms O-glcnacase activity 
ProteomicsProteomics of isolated human cerebral vessels and whole tissue
Cerebral vasculature is critical in maintaining brain health, as its dysfunction is linked to various neurological illnesses including dementia and stroke. Proteomic studies are integral in understanding the biological mechanism underlying this dysfunction, identifying potential therapeutic targets ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD055837 | Pride
Brain Dia Vasculature Human Isolation Healthy 
ProteomicsProteomics of TurboID-induced biotinylated proteins from astrocyte and astrocyte endeet after acute peripheral inflammation
The brain vasculature is tightly regulated to control the exchange of substances between the periphery and the brain parenchyma at an interface called the blood-brain barrier (BBB). Astrocytes are glial cells that wrap the brain vasculature with a specialised structure called the endfoot, which is a...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-11 | PXD056232 | Pride
Mouse Brain Dia Ip Endfoot Isolation Astrocyte 
UnknownAnalyses of the three 1-Cys Peroxiredoxins from Aspergillus fumigatus reveal that cytosolic Prx1 is central to H2O2 metabolism and virulence.
Not available
S-EPMC6098058 | biostudies-literature
UnknownCharacterization of Anti-Ana o 3 Monoclonal Antibodies and Their Application in Comparing Brazilian Cashew Cultivars.
Not available
S-EPMC8698838 | biostudies-literature
MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
UnknownLipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa.
Not available
S-EPMC5786101 | biostudies-literature
UnknownBiosynthesis and antifungal activity of fungus-induced O-methylated flavonoids in maize.
Not available
S-EPMC8774720 | biostudies-literature
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