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ProteomicsHDX-MS Analysis of CHK2 Incubated with Calmodulin
To determine the conformational dynamics upon binding of calmodulin to serine/threonine kinase CHK2.
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD048473 | Pride
Chk2 Calmodulin Hdx-ms 
ProteomicsChaperone Activation and Client Binding of a 2-Cysteine Peroxiredoxin
Many 2-Cys-peroxiredoxins (2-Cys-Prxs) serve as dual-function proteins. Active as peroxidases under non-stress conditions, they convert into effective chaperones under stress conditions. While their peroxidase activity has been extensively studied and shown to involve cycles of redox-mediated oligom...
ORGANISM(S): Leishmania infantum Photinus pyralis (Common eastern firefly) (Lampyris pyralis) 
2019-02-19 | PXD010281 | Pride
Cross-linking  chaperone activation  chaperone-client complex 
UnknownUnconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity.
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