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TranscriptomicsTranscription profiling of mouse CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3- T cells
Comparison of gene expression profile of CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3- T cells. Naive CD4+CD25-CD45RBhigh T cells were used as a reference for pair comparison with values from the three other subsets.
ORGANISM(S): Mus musculus 
2009-08-19 | E-MEXP-1343 | biostudies-arrayexpress
TranscriptomicsTwo functionally distinct subsets of mast cells generated through IL-2 independent CD25 activities
CD25 (IL-2R) can be expressed on the surface of immune cells in the absence of other chains of the interleukin-2 receptor (IL-2R), which are indispensable for IL-2 signaling. We identified two novel mast cell subsets, characterized by the differential expression of surface CD25, and by the ability t...
ORGANISM(S): Mus musculus 
2014-08-03 | E-GEOD-52502 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Foxp3- CD25- regulatory T cells
The concept of immune regulation/suppression has been well-established. With thymus-derived CD4 CD25 regulatory T (TR) cells, it became clear that a variety of additional peripherally induced TR cells play vital roles in protection from many harmful immune responses including intestinal inflammatio...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-12506 | biostudies-arrayexpress
TranscriptomicsNon-classical CD4+CD49b+ regulatory T cells as a better alternative to conventional CD4+CD25+ T cells to dampen arthritis severity
Regulatory T (Treg) cells actively control pathological immune responses and immunotherapeutic strategies triggering an increase in the number and/or the function of endogenous Treg cells emerge as a promising therapeutic strategy in autoimmune diseases to restore tolerance. A remarkable heterogenei...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-68621 | biostudies-arrayexpress
ProteomicsBioID of CD25 mutants in B-cell malignancies
CD25-dificient patient-derived PDX2 B-ALL cells and Jeko1 MCL cells with CRISPR-Cas9-mediated gene deletion were reconstituted with wild-type CD25 (S268) or CD25 carrying S268A mutant (A268) with C-terminal BirA (engineered biotin ligase) and selected by puromycin for 3 days. BirA expressing constru...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD035989 | Pride
Lc-msms B-all B-cell Cd25 Mcl Bioid Il2ra 
Transcriptomicsnaive-cd25 profiling
Naive T cell subsets in humans defined by CD25 expression
ORGANISM(S): Homo sapiens 
2013-02-21 | E-MTAB-1138 | biostudies-arrayexpress
TranscriptomicsHistone H3 Lysine 4 mono-, di- and trimethyl and CTCF in CD4+CD25+CD45RA+ regulatory and conventional CD4+CD25- T-cells
Analysis of Histone H3 Lysine 4 mono-, di- and trimethyl and the boundary protein CTCF in CD4+CD25+CD45RA+ regulatory T-cells and conventional CD4+CD25- T-cells. To investigate regulatory functions or potential new transcription start sites in Treg and Tconv cells, we investigated the associated hi...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-14234 | biostudies-arrayexpress
GenomicsGlobal Mapping of H3K4me1 and H3K4me3 in human CD4+CD25+FOXP3+ Treg cells
Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. However, the mechanisms underlying Treg function and cell fate decisions to differentiate between Treg and conventional T cells (Tconv) remain to be fully elucidated, especially at t...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26427 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human FoxP3+CD4+CD25+high regulatory T cells (Tregs) isolated from recent-onset type 1 diabetes mellitus (T1D) patients and controls
Naturally occurring FoxP3+CD4+CD25+high regulatory T cells (Tregs) play an important role in dominant tolerance, suppressing auto-reactive CD4+CD25- T cell activity. Although Tregs from T1D subjects are functionally deficient, there is little knowledge of the molecular mechanisms that orchestrate th...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-10586 | biostudies-arrayexpress
TranscriptomicsExpression data from cord blood derived CD4+ CD25+ (Treg) and CD4+ CD25- (Thelper) cells, both while resting & after stimulation
Here we compare the effects of stimulation on cord blood derived CD4+ CD25+ (Treg) and CD4+ CD25- (Thelper) cells, isolated by MACS protocols & expanded in vitro using dynabeads. Expansion was carried out at a ratio of 3 beads/cell in the presence of 1000units/ml of recombinant human IL2 for 8 days,...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-20934 | biostudies-arrayexpress
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