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ProteomicsQuantitative phosphoproteomic for CDKL5 substrates
Global phosphoproteomic screen to identify the first cellular substrates of CDKL5. CDKL5 knock-out U2OS cells and CDKL5 wt U2OS cells were generated for the TMT-based phosphoproteomic. Thi leads to the identification and further validation of several phosphopetides of MAP1S, CEP131 and CDKL5 itself....
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD009374 | Pride
Cdkl5 substrates Phosphoproteomic Tmt Ms2 
ProteomicsChemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics
Loss-of-function mutations in CDKL5 kinase causes severe neurodevelopmental delay and early-onset seizures. Identification of CDKL5 substrates is key to understanding its function. Using chemical genetics, we found that CDKL5 phosphorylates three microtubule-associated proteins: MAP1S, EB2 and ARHGE...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-18 | PXD010511 | Pride
Chemical genetics/ cdkl5/ map1s/ eb2/ microtubule dynamics 
ProteomicsCDKL5 substrates - Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase
Identification of CDKL5 substrates. Immuno-precipitated proteins were TMT labelled and analysed via LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD009327 | Pride
Cdkl5 Tmt Dlg5 map1s Cep131 
ProteomicsNuclear substrates of the CDKL5 kinase - Phosphoproteomics
Identification of nuclear substrates of the CDKL5 kinase by quantitative phosphoproteomics
ORGANISM(S): Homo sapiens (Human) 
2020-12-10 | PXD022916 | Pride
Cdkl5 Tmt Kinase Phosphoproteomics 
ProteomicsEpilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability
Developmental and epileptic encephalopathies (DEEs) are a group of rare childhood disorders characterized by severe epilepsy and cognitive deficits. Numerous DEE genes have been discovered thanks to advances in genomic diagnosis, yet putative molecular links between these disorders are unknown. CDKL...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-13 | PXD038505 | Pride
Cdkl5 Epilepsy Kinase Phosphoproteomics 
UnknownChemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics.
Not available
S-EPMC6293278 | biostudies-literature
UnknownPhosphoproteomic screening identifies physiological substrates of the CDKL5 kinase.
Not available
S-EPMC6293279 | biostudies-literature
UnknownChemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics
Not available
S-SCDT-EMBOJ-2018-99763 | biostudies-other
ProteomicsCDKL5 - nuclear substrates - Validation
Validation dataset for the kinase substrates identified in the phosphoproteomics dataset.
ORGANISM(S): Homo sapiens (Human) 
2020-12-10 | PXD022975 | Pride
Cdkl5 Tmt Kinase 
UnknownCyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder.
Not available
S-EPMC7293752 | biostudies-literature
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