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TranscriptomicsSOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate
Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state. However, without a tractable experimental model, the mechanism of human PGC (hPGC) specification remains unclear. Here, we demonstrate specification of hPGC-like cells (hPGCLCs) from germline competent pluripo...
ORGANISM(S): Homo sapiens 
2014-12-26 | E-GEOD-60138 | biostudies-arrayexpress
TranscriptomicsThe Polycomb protein Pcgf2/Mel18 regulates mesoderm cell fate-specification of embryonic stem cells through multiple mechanisms
Polycomb complexes are essential regulators of stem cell identity, yet very little is known about their molecular mechanisms during cell differentiation. Pcgf proteins (Pcgf1/2/3/4/5/6) are core subunits of the Polycomb repressive complex 1 (PRC1). It has been recently proposed that specific Pcgf pr...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-67868 | biostudies-arrayexpress
ProteomicsIntrinsic and extrinsic mechanisms alter neural cell fate specification in EPM1 Epilepsy
The extracellular milieu, including extracellular vesicles (EVs), plays a pivotal role in brain development by regulating neural processes such as proliferation, differentiation, and migration. In this study, we sought to elucidate the pathogenesis of progressive myoclonus epilepsy type 1 (EPM1), a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-21 | PXD072599 | Pride
Cell fate/cerebral organoids/cstb/epilepsy/extracellular vesicle/shh 
GenomicsPluripotency Factors Regulate Definitive Endoderm Specification through Eomesodermin
Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective towards the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types. Here, we used human embryonic stem cells (hESCs) to stud...
ORGANISM(S): Homo sapiens 
2011-01-25 | E-GEOD-26097 | biostudies-arrayexpress
ProteomicsGraded levels of p53 activation modulate endothelial cell fate and specification during angiogenesis
The cell cycle is a key regulator of endothelial cell specification into tip and stalk cell phenotypes, which are essential for angiogenesis in both normal development and pathological conditions. While the tumor suppressor p53 is known to regulate the cell cycle and influence cell fate, its role in...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD060120 | Pride
Angiogenesis P53 
TranscriptomicsTranscription profiling of mouse ventral forebrain cells in neuronal-glial fate specification and oligodendrocyte lineage maturation
This experiment compared the expression of mRNAs and noncoding RNAs during neuronal-glial fate specification and oligodendrocyte lineage maturation. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during this process.
ORGANISM(S): Mus musculus 
2010-01-07 | E-TABM-874 | biostudies-arrayexpress
TranscriptomicsGeminin-regulated genes during neural fate acquisition of mouse embryonic stem cells
Formation of the complex vertebrate nervous system begins when pluripotent cells of the early embryo are directed to acquire a neural fate. Although cell intrinsic controls play an important role in this process, the molecular nature of this regulation is not well defined. Here we assessed the rol...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25737 | biostudies-arrayexpress
UnknownSpatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification.
Not available
S-EPMC10942579 | biostudies-literature
ProteomicsDDX21 is a p38-MAPK sensitive nucleolar protein necessary for mouse preimplantation embryo development and cell-fate specification
2-cell (E1.5) stage embryos were cultured in normal KSOM+AA conditions until E3.5 +2h and thereafter 100 embryos each were moved to control or p38-MAPKi conditions and cultured for another 7 hours (E3.5 +9h). The embryos were then washed through pre-warmed (37˚C) Hank’s balanced salt solution (HBSS,...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-12 | PXD025754 | Pride
Lc-msms Preimplantation embryo development Ddx21 Cell fate specification P38-mapk 
TranscriptomicsGene expression analysis of adult and fetal T-cell progenitors
Development of T-cells provides a unique opportunity to study cell-fate determination due to the accessability and the well defined stages of developmental stages. In order to understand the genetic programs underlying fetal and adult T‑cell fate specification we subjected highly purified fetal and ...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-24142 | biostudies-arrayexpress
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