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Objective of this work was to characterize the miRNA profile of exosomes isolated from brain-homing cell lines (MDA-MB-231BR, CTC1BMSM, and 70W) with their respective parental non-brain metastatic cell lines (MDA-MB-231P, CTC1P and MeWo). Exosomes derived from the six cell lines were isolated. Brain...
ORGANISM(S): Homo sapiens 

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
we studied the role of exosomes isolated from M.tb infected macrophages in modulating the macrophage response to IFN-γ. Nimblegen microarray gene expression studies were used to compare the suppression of IFN-γ inducible genes by exosomes relative to the virulent strain of M.tuberculosis. Overall ou...
ORGANISM(S): Mus musculus 
Microarray analysis of exosomal miRNAs vs the miRNAs of their respective donor cells. To determine the miRNA repertoires of exosomes secreted by immune cells, we isolated exosomes from cell supernatants of the Raji B cell line, the Jurkat-derived J77 T cell line, and primary dendritic cells (DCs) de...
ORGANISM(S): Homo sapiens 
Exosomes are small extracellular nano-vesicles of endocytic origin that mediate different signals between cells, by surface interactions and by shuttling of functional RNA from one cell to another. In this study, we show that exosomes, produced by mouse mast cells exposed to oxidative stress, change...
ORGANISM(S): Mus musculus 
Human mesenchymal stem cell (MSC)-conditioned medium (CM) was previously reported to affect the biology of tumor cells; however, the precise mechanisms remain unclear. Here, we show that MSCs secreted 40- to 100-nm particles, which have the typical characteristics of exosomes, and these MSC-derived ...
ORGANISM(S): Homo sapiens 
To detect the differential expressed proteins in bladder cancer(BCa)-derived exosomes, we isolated BCa cell-derived exosome and normal bladder epithelial cell-derived exosomes. The quantitative proteomics were conducted to detect the upregulated proteins in BCa cell-derived exosomes compared with SV...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053106 | Pride
miRNA sequencing of Mesenchymal stem cells-derived exosomes and MRC-5 cell-derived exosomes
We compared the differential proteins between Mesenchymal stem cells-derived exosomes MRC-5 cell-derived exosomes.
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD033839 | Pride
Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD) and renal fibrosis, suggesting intimate communication between the two diseases. However, the underlying mechanisms remain to be determined. Exosomes play a role in shuttling proteins and other mater...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030696 | Pride
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