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MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
TranscriptomicsDirect contact with mesenchymal stromal cells impacts CD133+ hematopoietic stem cells during ex-vivo expansion
Direct contact with mesenchymal stromal impacts on migratory behavior and gene expression profile of CD133+ hematopoietic stem cells during ex-vivo expansion Objective: To investigate the impact of direct contact between mesenchymal stromal cells (MSCs) and CD133+ hematopoietic stem cells (HSCs) in ...
ORGANISM(S): Homo sapiens 
2008-11-12 | E-GEOD-13566 | biostudies-arrayexpress
TranscriptomicsNickel-induced contact dermatitis induce changes in human skin transcriptome over 96 hours
We aimed to characterize transcriptomic changes over time (baseline, 2 hours, 48 hours and 96 hours) after nickel-induced contact dermatitis in 6 human probands. As a contrast, 7 patients with SLS-induced irritant contact dermatitis were included. Therefore, the patch tests were applied onto the bac...
ORGANISM(S): Homo sapiens 
2020-05-01 | E-MTAB-8945 | biostudies-arrayexpress
MetabolomicsIn-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level
Comprehensive single-cell metabolic profiling is critical for revealing phenotypic heterogeneity and elucidating the molecular mechanisms underlying biological processes. However, single-cell metabolomics remains challenging because of the limited metabolite coverage and inability to discriminate is...
2026-08-14 | MTBLS8113 | MetaboLights
TranscriptomicsQuiescent Fibroblasts Exhibit High Metabolic Activity
Many cells in mammals exist in the state of quiescence, which is characterized by reversible exit from the cell cycle. Quiescent cells are widely reported to exhibit reduced size, nucleotide synthesis, and metabolic activity. Much lower glycolytic rates have been reported in quiescent compared with ...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-42612 | biostudies-arrayexpress
ProteomicsPI3K-AKT pathway and cell-cell contact regulates maspin nuclear localization
Background: Maspin (SERPINB5) is a potential tumor suppressor gene with pleiotropic biological activities, including regulation of cell proliferation, death, adhesion, migration and gene expression. Several studies indicate that nuclear localization is essential for maspin tumor suppression activity...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023224 | Pride
Cell-to-cell contact Jak-stat Maspin Egfr Pi3k-akt 
TranscriptomicsContact versus contactless signatures in myeloma
The intracellular pathways regulated by intercellular interactions within the myelomatous bone marrow (BM) were studied by analysis of the changes in gene expression profile (GEP) following interruption of the natural interactions due to BM aspiration. Among numerous changes in GEP evolved, a subset...
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-36036 | biostudies-arrayexpress
GenomicsSLAMF1 is regulated by macrophage-CD4 T cell contact and confers protection to Mycobacterium tuberculosis
SLAMF1 is regulated by macrophage-CD4 T cell contact and confers protection to Mycobacterium tuberculosis
PRJNA929491 | ENA
TranscriptomicsInterbacterial signaling via Burkholderia contact-dependent growth inhibition proteins
In prokaryotes and eukaryotes, cell-cell communication and recognition of self are critical to coordinate multicellular functions. While kin and kind discrimination are increasingly appreciated to shape naturally occurring microbe populations, the underlying mechanisms that govern these interbacteri...
ORGANISM(S): Burkholderia thailandensis 
2016-08-09 | E-GEOD-83143 | biostudies-arrayexpress
GenomicsRNA candidate screening in cell-to-cell contact-induced differentiation of human Pulmonary Artery Smooth Muscle Cells (hPASMC, Lonza)
RNA candidate screening in cell-to-cell contact-induced differentiation of human Pulmonary Artery Smooth Muscle Cells (hPASMC, Lonza)
PRJNA1011950 | ENA
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