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ProteomicsPI3K-AKT pathway and cell-cell contact regulates maspin nuclear localization
Background: Maspin (SERPINB5) is a potential tumor suppressor gene with pleiotropic biological activities, including regulation of cell proliferation, death, adhesion, migration and gene expression. Several studies indicate that nuclear localization is essential for maspin tumor suppression activity...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023224 | Pride
Cell-to-cell contact Jak-stat Maspin Egfr Pi3k-akt 
ProteomicsPulldown of Maspin-GST in Human Cells Treated or Untreated with Nocodazole
Human cells, either asynchronous or synchronized with nocodazole, were subjected to a pulldown assay using GST-maspin. Interacting proteins were eluted using 10 mM reduced glutathione, 150 mM NaCl, 1 mM DTT, and 50 mM Tris-HCl (pH 8.5).
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD057847 | Pride
Pulldown Human cells Nocodazole Maspin 
TranscriptomicsDysregulated deltaNp63alpha negatively regulates p73-mediated maspin expression
The p53 homologue, p63, is critical for normal epidermal development. While overexpression of deltaNp63alpha has been reported in squamous cell cancers, the contribution of p63 to cancer pathogenesis remains unclear. We previously demonstrated that overexpressed deltaNp63alpha aberrantly maintains p...
ORGANISM(S): Mus musculus 
2013-02-26 | E-GEOD-34862 | biostudies-arrayexpress
GenomicsGene expression profiles in maspin-overexpressing MDA-MB-231 breast cancer cells
Gene expression profiles in maspin-overexpressing MDA-MB-231 breast cancer cells
PRJNA602620 | ENA
TranscriptomicsGene expression profiles in maspin-overexpressing MDA-MB-231 breast cancer cells
A comparison of gene expression profiles between control- and mascpin-overexpressing MDA-MB-231 cells was performed to investigate the role of cytoplasmic maspin in breast cancer progression. The data provides insight into the importance of cytoplasmic maspin in breast cancer progression.
ORGANISM(S): Homo sapiens 
2020-07-22 | GSE144044 | GEO
TranscriptomicsDysregulated deltaNp63alpha negatively regulates p73-mediated maspin expression
The p53 homologue, p63, is critical for normal epidermal development. While overexpression of deltaNp63alpha has been reported in squamous cell cancers, the contribution of p63 to cancer pathogenesis remains unclear. We previously demonstrated that overexpressed deltaNp63alpha aberrantly maintains p...
ORGANISM(S): Mus musculus 
2013-02-26 | GSE34862 | GEO
TranscriptomicsGene expression profiles in maspin-overexpressing RERF-LC-AI and LK-2 lung squamous cell carcinoma cell lines
To investigate the subcellular localization of maspin in lung squamous cell carcinoma (LUSC) and its functional relevance, gene expression profiles were analyzed in RERF-LC-AI and LK-2 cells overexpressing maspin. The data provides insight into the differential function of maspin in LUSC depending o...
ORGANISM(S): Homo sapiens 
2021-07-27 | GSE180712 | GEO
GenomicsGene expression profiles in maspin-overexpressing RERF-LC-AI and LK-2 lung squamous cell carcinoma cell lines
Gene expression profiles in maspin-overexpressing RERF-LC-AI and LK-2 lung squamous cell carcinoma cell lines
PRJNA749271 | ENA
UnknownP176S Mutation Rewires Electrostatic Interactions That Alter Maspin Functionality.
Not available
S-EPMC10413834 | biostudies-literature
UnknownMaspin is not required for embryonic development or tumour suppression.
Not available
S-EPMC3905777 | biostudies-literature
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