Sort   by:  
 Page size 
MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
MetabolomicsStress-related mitogen-activated protein kinases stimulate the accumulation of small molecules and proteins in Arabidopsis thaliana root exudates
A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...
2017-08-25 | MTBLS441 | MetaboLights
ProteomicsCross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
Herpesviruses encode conserved protein kinases to optimize virus infection by targeted phosphorylation. How these kinases bind to cellular factors and how this impacts their regulatory functions is poorly understood. Here, we use quantitative proteomics to determine the interactomes of eight herpesv...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Herpesvirales 
2020-08-13 | PXD016334 | Pride
Hcmv Ebv Conserved herpesvirus protein kinases Hsv-1 Mcmv 
TranscriptomicsChromatin immunoprecipitation of activated yeast signal transduction protein kinases
Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which they regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protei...
ORGANISM(S): Saccharomyces cerevisiae 
2006-07-28 | E-TABM-98 | biostudies-arrayexpress
GenomicsDegradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia
We evaluated the efficacy of proteolysis-targeting chimeras (PROTACs) directed against Janus kinases. Solving the structure of FDA-approved type I JAK inhibitors ruxolitinib and baricitinib bound to the JAK2 JH1 tyrosine kinase domain enabled the rational design and optimization of Cereblon (CRBN)-d...
EGAS00001005180 | EGA
ProteomicsA microscopy-based screen identifies cellular kinases modulating mitochondrial translation
Mitochondrial DNA encodes thirteen subunits of the oxidative phosphorylation (OXPHOS) system, which are synthesized inside the organelle and essential for cellular energy supply. How mitochondrial gene expression is regulated and integrated into cellular physiology is little understood. Here, we per...
ORGANISM(S): Homo sapiens (Human) 
2025-01-02 | PXD053045 | Pride
Mitochondrial translation Dia Immunoisolation Cellular kinases Sirna library Click chemistry 
TranscriptomicsTranscription profiling of human A549 lung cancer cells treated with compounds from a series of inhibitors developed against the human LIM kinases LIMK1 and LIMK2
To investigate an unknown mechanism of cytotoxicity, A549 human lung-cancer cells were treated with compounds from a series of inhibitors developed against the human LIM kinases LIMK1 and LIMK2. Compounds 1 and 2 inhibit LIM kinase activity in vitro and affect cell proliferation and survival in vivo...
ORGANISM(S): Homo sapiens 
2008-09-17 | E-TABM-450 | biostudies-arrayexpress
TranscriptomicsThe effect of knockdown Abl kinases on breast cancer cells' global transcriptome
To gain insight into the signaling pathway(s) required for ABL1/ABL2-dependent bone metastasis, we evaluated the consequences of single or double inactivation of ABL1 and ABL2 on the transcriptome of breast cancer cells. Double ABL1/ABL2 knockdown was required to decrease the levels of p-CrKL by mor...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-69125 | biostudies-arrayexpress
ProteomicsRegulation of the Golgi apparatus by p38 and JNK kinases during cellular stress responses
p38 and JNK are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics...
ORGANISM(S): Homo sapiens (Human) 
2021-09-13 | PXD028151 | Pride
P38 Jnk Golgi 
ProteomicsYeast AGC-kinases phospho-proteomics
Protein phosphorylation cascades play a central role in the regulation of cell growth and protein kinases PKA, Sch9 and Ypk1 take centre stage in regulating this process in S. cerevisiae. To understand how these kinases co-ordinately regulate cellular functions we compared the phospho-proteome of ex...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-27 | PXD015668 | Pride
Ypk1 Chemical genetics Agc-kinases Pka Sch9 S. cerevisiae 
Sort   by:  
 Page size