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ProteomicsDeciphering TRIM69 interactors and its phosphor-proteomic regulation in centrosome dynamics
Stringent control of centrosome duplication and separation is important for preventing chromosome instability. Structural and numerical alterations in centrosomes are hallmarks of neoplastic cells and contribute to tumorigenesis. We show that a Centrosome Amplification 20 (CA20) gene signature is a...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042098 | Pride
Kgg Centrosome dynamics Phosphoproteomic profiling Ip mass-spectrometry 
ProteomicsSpatial centrosome proteome of human neural cells uncovers novel interactors and disease hubs
Despite the crucial importance of the centrosome in brain development and disease, its comprehensive proteome remains uncharacterized in neural cells. Here, we used spatial proteomics to elucidate protein interaction networks at the centrosome of iPSC-derived human neural stem cells (NSCs) and neuro...
ORGANISM(S): Homo sapiens (Human) 
2022-06-22 | PXD031936 | Pride
Neuron Neural stem cells Neurodevelopmental disorder Human brain Rna splicing Centrosome Interactome 
UnknownCortical actin dynamics facilitate early-stage centrosome separation.
Not available
S-EPMC3032811 | biostudies-literature
TranscriptomicsSpatial centrosome proteome of human neural cells uncovers novel interactors and disease hubs
Despite the crucial importance of the centrosome in brain development and disease, its comprehensive proteome remains uncharacterized in neural cells. Here, we used spatial proteomics to elucidate protein interaction networks at the centrosome of iPSC-derived human neural stem cells (NSCs) and neuro...
ORGANISM(S): Mus musculus 
2022-06-15 | GSE201954 | GEO
UnknownCharacterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome.
Not available
S-EPMC4880864 | biostudies-literature
UnknownATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics.
Not available
S-EPMC5045193 | biostudies-literature
UnknownAsymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo.
Not available
S-EPMC11906807 | biostudies-literature
GenomicsSpatial centrosome proteome of human neural cells uncovers novel interactors and disease hubs
Spatial centrosome proteome of human neural cells uncovers novel interactors and disease hubs
PRJNA833732 | ENA
UnknownPCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate.
Not available
S-EPMC12663461 | biostudies-literature
UnknownInter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination.
Not available
S-EPMC5653239 | biostudies-literature
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