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ProteomicsSelective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that autophagy preserve...
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD014829 | Pride
Centrosome Selective autophagy Centrosome fragmentation Gabarap Mitosis Cep131 Autophagy Centriolar satellites Pcm1 
TranscriptomicsZNF131 suppresses centrosome fragmentation in Glioblastoma stem-like cells through regulation of HAUS5
To identify new Glioblastoma multiforme (GBM) therapeutic strategies, we previously performed genome-wide RNAi lethality screens in patient-derived GBM stem-like cells (GSCs) and neural progenitor cells (NPCs) to identify genes required for the self-renewal of GSC isolates, but which are dispensable...
ORGANISM(S): Homo sapiens 
2018-02-06 | GSE95027 | GEO
ProteomicsSpatial centrosome proteome of human neural cells uncovers novel interactors and disease hubs
Despite the crucial importance of the centrosome in brain development and disease, its comprehensive proteome remains uncharacterized in neural cells. Here, we used spatial proteomics to elucidate protein interaction networks at the centrosome of iPSC-derived human neural stem cells (NSCs) and neuro...
ORGANISM(S): Homo sapiens (Human) 
2022-06-22 | PXD031936 | Pride
Neuron Neural stem cells Neurodevelopmental disorder Human brain Rna splicing Centrosome Interactome 
UnknownPrecocious centriole disengagement and centrosome fragmentation induced by mitotic delay.
Not available
S-EPMC5474744 | biostudies-literature
TranscriptomicsGene expression in mitotic tissues of Drosophila larvae without centrosomes or too many centrosomes
Centrosome defects are a common feature of many cancers. Surprisingly, flies can proceed through the majority of development without centrosomes or with amplified centrosomes in most of their cells. It is unclear whether this is because centrosome defects do not cause many problems in Drosophila cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-20 | E-GEOD-35240 | biostudies-arrayexpress
UnknownZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5.
Not available
S-EPMC5564707 | biostudies-literature
ProteomicsDeciphering TRIM69 interactors and its phosphor-proteomic regulation in centrosome dynamics
Stringent control of centrosome duplication and separation is important for preventing chromosome instability. Structural and numerical alterations in centrosomes are hallmarks of neoplastic cells and contribute to tumorigenesis. We show that a Centrosome Amplification 20 (CA20) gene signature is a...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042098 | Pride
Kgg Centrosome dynamics Phosphoproteomic profiling Ip mass-spectrometry 
GenomicsHomo sapiens
ZNF131 suppresses centrosome fragmentation in Glioblastoma stem-like cells through regulation of HAUS5
PRJNA375764 | ENA
UnknownDNA damage induces Chk1-dependent centrosome amplification.
Not available
S-EPMC2002539 | biostudies-literature
TranscriptomicsUsp44 binds centrin to regulate centrosome positioning and suppress tumorigenesis
Most human tumors have abnormal numbers of chromosomes, a condition known as aneuploidy. The mitotic checkpoint is an important mechanism that prevents aneuploidy through restraining the activity of the anaphase-promoting complex (APC). USP44 was identified as a key regulator of APC activation that ...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-40791 | biostudies-arrayexpress
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