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ProteomicsLRRK2-RAB12 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in Astrocytes
Leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of RAB GTPases and this phosphorylation is elevated by Parkinson’s disease (PD)-linked mutations of LRRK2. However, the precise function of the specific RAB GTPase targeted by LRRK2 signaling remains to be elucidated. Here we solve the str...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-18 | PXD048732 | Pride
Structure of lrrk2-rab12 protein complex Proteomics Lrrk2 Ciliogenesis Centrosome homeostasis Parkinson’s disease Tandem mass tag 
ProteomicsSelective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that autophagy preserve...
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD014829 | Pride
Centrosome Selective autophagy Centrosome fragmentation Gabarap Mitosis Cep131 Autophagy Centriolar satellites Pcm1 
TranscriptomicsGene expression in mitotic tissues of Drosophila larvae without centrosomes or too many centrosomes
Centrosome defects are a common feature of many cancers. Surprisingly, flies can proceed through the majority of development without centrosomes or with amplified centrosomes in most of their cells. It is unclear whether this is because centrosome defects do not cause many problems in Drosophila cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-20 | E-GEOD-35240 | biostudies-arrayexpress
ProteomicsFbxl13 regulates centrosome homeostasis and migration through ubiquitin mediated proteolysis
F-box proteins are the variable substrate adaptor subunits of the SCF (Skp1, Cul1, F-box) ubiquitin ligases. The family comprise about 69 members with important roles in cancer pathogenesis and cell proliferation. Among the F-box proteins, Fbxl13 is frequently amplified in several cancer patient coh...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD006756 | Pride
Ubiquitin ligase Hek293t Fbxl13 Orbitrap elite F-box protein 
ProteomicsFBXL13 regulates centrosome homeostasis and migration through ubiquitin- mediated proteolysis
Aberrant centrosome organization with ensuing alterations of microtubule nucleation enables tumor cells to proliferate and invade despite increased genomic instability. CEP192 is a key factors in the initiation process of centrosome duplication and in the control of centrosome microtubule nucleation...
ORGANISM(S): Homo sapiens (Human) 
2018-01-16 | PXD008310 | Pride
Ubiquitin fbxl13 
UnknownNucleoporin Nup62 maintains centrosome homeostasis.
Not available
S-EPMC3905072 | biostudies-literature
UnknownRAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.
Not available
S-EPMC11439917 | biostudies-literature
UnknownRAB12-LRRK2 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in Astrocytes.
Not available
S-EPMC11275936 | biostudies-literature
GenomicsCentrosome clustering in osteoclasts regulated by CCR5-mediated signaling, involved in bone homeostasis
Centrosome clustering in osteoclasts regulated by CCR5-mediated signaling, involved in bone homeostasis
PRJNA941801 | ENA
UnknownPPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion.
Not available
S-EPMC6249868 | biostudies-literature
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