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ProteomicsHELA cells Sphingolipid pulldown (Cers6 and Cers5)
Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of obesity and insulin resistance. However, the mechanistic link between both processes remains unclear. Here we demonstrate that abrogation of ceramide synthase (CerS)6, which generates C16:0-sphingolipids, bu...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD007158 | Pride
Hela Cer6 Cers5 Sphingolipid Click chemistry 
UnknownCerS1 but Not CerS5 Gene Silencing, Improves Insulin Sensitivity and Glucose Uptake in Skeletal Muscle.
Not available
S-EPMC8773817 | biostudies-literature
UnknownHigh CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer.
Not available
S-EPMC4858121 | biostudies-literature
GenomicsEffect of knocking down CERS2 or a double knockdown (KD) CERS5/6 in ventricular cardiomyocytes on gene expression under conditions of hypertrophy induced by phorbol 12-myristate 13-acetate (PMA) or controls.
Effect of knocking down CERS2 or a double knockdown (KD) CERS5/6 in ventricular cardiomyocytes on gene expression under conditions of hypertrophy induced by phorbol 12-myristate 13-acetate (PMA) or controls.
PRJNA1201240 | ENA
TranscriptomicsEffect of knocking down CERS2 or a double knockdown (KD) CERS5/6 in ventricular cardiomyocytes on gene expression under conditions of hypertrophy induced by phorbol 12-myristate 13-acetate (PMA) or controls.
Sphingolipids are an important class of lipids that play imperative structural and functional roles in the body. Ceramides constitute the central essential structural backbone of more complex sphingolipids, thus alterations in the genes that regulate their expression could dysregulate the entire cel...
ORGANISM(S): Homo sapiens 
2025-08-27 | GSE285142 | GEO
ProteomicsComplexome profiling to study consequences of membrane protein complexes in cells with knock down of ceramide synthase 4 and 5 in HCT-116 and Caco-2 cells.
Ceramide synthases are central enzymes of the sphingolipid pathway and are important for the production of sphingolipids of different chain length. Sphingolipids of different chain length impact the physicochemical properties of membranes. Here we investigated by complexome profiling how the expres...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD030604 | Pride
Lc-msms Complexome profiling 
UnknownHigh expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer.
Not available
S-EPMC9552061 | biostudies-literature
UnknownA tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle.
Not available
S-EPMC6974707 | biostudies-literature
UnknownCeramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
Not available
S-EPMC7409364 | biostudies-literature
UnknownMyristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cells.
Not available
S-EPMC6133702 | biostudies-literature
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