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TranscriptomicsTranscriptome analysis of human WhartonM-bM-^@M-^Ys jelly stem cells
Human WhartonM-bM-^@M-^Ys jelly stem cells (hWJSCs) are derived ethically in large amounts from the umbilical cord matrix. Besides their differentiation capabilities, WJSCs also display a notable lack of ability to form teratoma. hWJSCs have been shown to exert immunomodulatory effects and have rece...
ORGANISM(S): Homo sapiens 
2010-07-25 | E-GEOD-20126 | biostudies-arrayexpress
TranscriptomicsCellodextrin utilization by Bifidobacterium breve UCC2003
The transcription of the cldEFGC gene cluster of Bifidobacterium breve UCC2003 was shown to be induced upon growth on cellodextrins, implicating these genes in the metabolism of these sugars. Phenotypic analysis of a B. breve UCC2003::cldE insertion mutant confirmed that the cld gene cluster is excl...
ORGANISM(S): Bifidobacterium breve UCC2003 
2010-08-11 | E-GEOD-17604 | biostudies-arrayexpress
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
TranscriptomicsThe effect of nicotinamide on dysregulated genes associated with frataxin deficiency in FRDA.
To investigate the efficacy of nicotinamide treatment using our ex-vivo primary lymphocyte model, we performed high-throughput RNA sequencing on libraries generated from untreated and nicotinamide treated samples. PBMC isolated from FRDA affected individuals were cultured to prepare the primary lymp...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-42960 | biostudies-arrayexpress
UnknownIvabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer
Not available
S-EPMC12323259 | biostudies-literature
ProteomicsPrenatal low-dose MeHg exposure leads to proteomic and transcriptomic alterations consistent with neurodegenerative disease in the cerebellum of C57BL/6 mice
Methylmercury (MeHg) is a global pollutant that readily crosses the blood–brain barrier and placenta, posing significant risks to fetal neurodevelopment. While the cerebellum is a recognized target of MeHg toxicity in adults, the mechanisms underlying fetal exposure remain poorly defined. In this st...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-06 | PXD068503 | Pride
Proteomics Mehg Prenatal Disease latency Cerebellum Transcriptomics Neurodegenerative disease 
TranscriptomicsMetabolism of four α-glycosidic linkage-containing oligosaccharides by Bifidobacterium breve UCC2003
Members of the genus Bifidobacterium are common inhabitants of the gastrointestinal tract of humans and other mammals, where they ferment many diet-derived carbohydrates that cannot be digested by their host. To extend our understanding of bifidobacterial carbohydrate utilisation, we investigated th...
ORGANISM(S): Bifidobacterium breve 
2013-08-16 | E-GEOD-47448 | biostudies-arrayexpress
TranscriptomicsRibose utilization by the human commensal Bifidobacterium breve UCC2003
Growth of B. breve UCC2003 on ribose leads to the transcriptional induction of the rbsACBDK gene cluster. Generation and phenotypic analysis of an rbsA insertion mutant established that the rbs gene cluster is essential for ribose utilization, and that its transcription is likely regulated by a LacI...
ORGANISM(S): Bifidobacterium breve UCC2003 
2010-05-19 | E-GEOD-17325 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human WhartonM-bM-^@M-^Ys jelly stem cells: meta-analysis
Human WhartonM-bM-^@M-^Ys jelly stem cells (hWJSCs) are derived ethically in large amounts from the umbilical cord matrix. Besides their differentiation capabilities, WJSCs also display a notable lack of ability to form teratoma. hWJSCs have been shown to exert immunomodulatory effects and have rece...
ORGANISM(S): Homo sapiens 
2010-07-18 | E-GEOD-20125 | biostudies-arrayexpress
TranscriptomicsMetabolism of a plant derived galactose-containing polysaccharide by Bifidobacterium breve UCC2003
In this study, we describe the functional characterisation of the B. breve UCC2003 gal locus, which is dedicated to the utilisation of galactan, a plant-derived polysaccharide. Using a combination of molecular approaches we conclude that the galA gene of B. breve UCC2003 encodes a beta-1,4-endogalac...
ORGANISM(S): Bifidobacterium breve UCC2003 
2012-05-16 | E-GEOD-21865 | biostudies-arrayexpress
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