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ProteomicsNovel proteolysis targeting chimera (PROTAC) selectively targeting Leucine Zipper-bearing Kinase (LZK) limits oncogenic potential of head and neck cancers.
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD054481 | Pride
Leucine zipper-bearing kinase Lzk Head and neck cancer Targeted protein degradation Protac Map3k13 Proteolysis targeting chimera Hnscc 
Proteomics,MultiomicsMudPIT analyses of the proteins associated with IFZK3 and IFZK1 in a human multiple myeloma cell line, ARP-1
IKZF1 and IKZF3 are transcription factors highly expressed in myeloma and contribute to myeloma cell survival. To better understand the function of IKZFs, we sought out to identify novel physiologic partners. To this purpose we generated a human MM cell line, ARP-1, stably expressing physiologic l...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-13 | MSV000081712 | MassIVE
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Not available
S-EPMC11224843 | biostudies-literature
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