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TranscriptomicsTRRAP-mediated regulation of Wee1
The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry through the dual regulation of Wee1 and Cdc25 by the Chk1 effector kinase. Up-regulation of Chk1 by mutation or overexpression bypasses the requirement for up-stream regulators or DNA damage to promote a G2 cell cycle arrest. We screened i...
ORGANISM(S): Schizosaccharomyces pombe 
2010-04-11 | E-GEOD-12674 | biostudies-arrayexpress
ProteomicsSPARTAN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards Genome Stability
DNA-protein crosslinks (DPCs) are abundant DNA lesions, which constantly challenge genome stability by interfering with DNA replication. SPARTAN (SPRTN) protease plays a central role in DPCs repair in proliferative vertebrate cells. SPRTN is a constitutive part of the DNA replication machinery and i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD006741 | Pride
Cancer Spartan protease Dna-protein crosslinks Ageing Genome stability Chk1 kinase Dna replication 
ProteomicsIdentification of post translational modifications of human Topoiosmerase 1 in the presence of camptothecin and CHK1 inhibitor SCH900776.
Topisomerase 1 (TOP1), an essential enzyme in humans, plays a critical role in relaxation of DNA supercoils during replication and transcription. The TOP1 reaction cycle involves an obligate TOP1-DNA covalent complex intermediate (TOP1cc), which is stabilized by TOP1 poisons like camptothecin. While...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD055870 | Pride
Topoisomerase 1 Mk-8776 Chk1 Sch900776 Camptothecin 
ProteomicsPhosphoproteomics analysis of CHK1 inhibitor treatment
Inhibitors of checkpoint kinase 1 (CHK1),a central component of DNA damage and cell cycle checkpoint response, represent a promising new cancer therapy, but the global cellular functionsthey regulate through phosphorylationare poorly understood. To elucidate the CHK1-regulated phosphorylation networ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD015125 | Pride
Chk1 inhibitor Silac Phosphoprotomics 
ProteomicsThe phosphoproteomics study of Chk1 and ATR inhibitors regulation on cells
Ataxia Telangiectasia and Rad3-related (ATR) and Checkpoint Kinase 1 (Chk1) are crucial kinases in the DNA Damage Response (DDR) pathway. While the roles of ATR and Chk1 within the DDR are well-established, their roles in mitosis are not fully understood. Here, we describe that the ATR-Chk1 pathway ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD058541 | Pride
Phosphoproteomics Cdk1 Inhibitor Chk1 
UnknownCheckpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1).
Not available
S-EPMC1567681 | biostudies-literature
UnknownKinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.
Not available
S-EPMC3358916 | biostudies-literature
UnknownPhosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.
Not available
S-EPMC4424366 | biostudies-literature
ProteomicsHistone H3 Serine-57 phosphorylation by CHK1 promotes responses to DNA replication stress
Post-translational modifications (PTM) of chromatin control the genomic environment for transcription, DNA replication and repair in response to cell stimuli1–3. Replication stress in budding and fission yeasts leads to abundant acetylation of histone H3 on lysine-56 (H3K56ac)4–6, but only trace lev...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2022-02-10 | PXD011328 | Pride
Histone post-translational modifications H3s57ph Checkpoint kinase 1 (chk1) Chromatin Dna replication stress 
TranscriptomicsDNA damage checkpoint kinases regulate a global network of transcription factors
DNA damage results in the activation of checkpoint kinases, which phosphorylate downstream effectors that inhibit the cell cycle, activate DNA repair, and cause widespread changes in transcription. However, the specific connections between the checkpoint kinases and downstream transcription factors ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-31 | E-GEOD-40351 | biostudies-arrayexpress
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