Sort   by:  
 Page size 
TranscriptomicsImproved detection of global copy number variation using high density, non-polymorphic oligonucleotide probes
Goal: To identify copy number variation in normal individuals using high density, non-polymorphic oligonucleotide probes Background DNA sequence diversity within the human genome may be more greatly affected by copy number variations (CNVs) than single nucleotide polymorphisms (SNPs). Although the ...
ORGANISM(S): Homo sapiens 
2008-04-24 | E-GEOD-9053 | biostudies-arrayexpress
GenomicsPseudouridine-chemical probes-Nanopore direct RNA sequencing
Pseudouridine-chemical probes-Nanopore direct RNA sequencing
PRJEB51316 | ENA
GenomicsMicrobiota Functional Analysis by Chemical Probes
Five microbiota communities were analyzed for functional capacity to transform chemical probes spiked into ex vivo fermentations.
PRJEB115360 | ENA
ProteomicsValidation and invalidation of chemical probes for the human N-myristoyltransferases.
On-target, cell-active chemical probes are of fundamental importance in both chemical and cell biology, whereas the application of poorly-characterised probes often leads to invalid conclusions. Human N-myristoyltransferase (NMT) has attracted increasing interest as a target in cancer and infectious...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD012722 | Pride
N-myristoylation Imp-366 (ddd85646) Metabolic tagging Tris-dba palladium Myristic acid alkyne ynmyr Chemical proteomics Imp-1088 D-nmappd (b13) 2-hydroxymyristic acid 
ProteomicsChemical probes unravel an antimicrobial defense response triggered by binding of the human opioid dynorphin to a bacterial sensor kinase
Host-microbe communication via small molecule signals is often poorly understood at the molecular level. Under conditions of host stress, levels of the human opioid peptide dynorphin are elevated, triggering virulence in the opportunistic pathogenic bacterium Pseudomonas aeruginosa (PAO1) via an unk...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2017-04-03 | PXD006172 | Pride
Photoaffinity probes Host-microbe communication Pseudomonas aeruginosa 
ProteomicsAza-SAHA Derivatives are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation
We report the first selective chemical probes for histone deacetylase 10 (HDAC10) with unprecedented selectivity over other HDAC isozymes. HDAC10 deacetylates polyamines and has a distinct substrate specificity, making it unique among the 11 zinc-dependent HDAC hydrolases. Taking inspiration from HD...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD032671 | Pride
Histone deacetylase Polyamines Be(2)-c Drug discovery Chemical proteomics Chemical biology Chemical probes Lc-ms/ms 
GenomicsProteomic discovery of chemical probes that perturb protein complexes in human cells
Proteomic discovery of chemical probes that perturb protein complexes in human cells
PRJNA909188 | ENA
ProteomicsMapping Protein Targets of Bioactive Small Molecules using Lipid-Based Chemical Proteomics
Lipids play critical roles in cell biology, often through direct interactions with proteins. We recently described the use of photoreactive lipid probes combined with quantitative mass spectrometry to globally map lipid-protein interactions, and the effects of drugs on these interactions, in cells. ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-26 | PXD007570 | Pride
Hek293t Neuro2a Orbitrap velos Chemoproteomics Lipid probes 
GenomicsProteomic discovery of chemical probes that perturb protein complexes in human cells II
Proteomic discovery of chemical probes that perturb protein complexes in human cells II
PRJNA911743 | ENA
UnknownChemical probes of histone lysine methyltransferases.
Not available
S-EPMC4301070 | biostudies-literature
Sort   by:  
 Page size