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UnknownLong-Term Follow-Up of a Community Assignment, One-Time Endoscopic Screening Study of Esophageal Cancer in China.
Not available
S-EPMC4881309 | biostudies-literature
ProteomicsImmunoprecipitation of PTEN coupled Nano-LC−ESI-MS/MS
Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However, nuclear PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that nuclear PTEN is more unstable than...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017983 | Pride
Immunoprecipitation Pten Nano-lc−esi-ms/ms 293t 
ProteomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis
PTEN, a widely investigated tumor suppressor, has at least two longer translational variants, PTEN and . However, the regulation and precise roles of endogenous PTEN/ in tumorigenesis remain greatly unknown. Here we show that USP9X and FBXW11 selectively regulate the stability of PTEN/ but not PTEN ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD013196 | Pride
Ptena  ptenb  pten  usp9x  fbxw11  ubiquitination wdr5  carcinogenesis 
ProteomicsNuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role
Dysregulation of pre-mRNA alternative splicing (AS) is closely associated with cancers. However, the relationships between the AS and classic oncogenes/tumor suppressors are largely unknown. Here we show that the deletion of tumor suppressor PTEN alters pre-mRNA splicing in its phosphatase-independe...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD009681 | Pride
U2af2 Golgi Tumor suppressor Spliceosome Pten Golga2 Protein-protein interaction Alternative splicing 
UnknownHypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells.
Not available
S-EPMC8438024 | biostudies-literature
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
ProteomicsHypoxia Regulates Overall mRNA Homeostasis by Inducing Met1-linked Linear Ubiquitination of AGO2 in Cancer Cells
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...
ORGANISM(S): Homo Sapiens 
PXD021722 |
UnknownToripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial.
Not available
S-EPMC12371549 | biostudies-literature
UnknownProtecting stable biological nomenclatural systems enables universal communication: A collective international appeal.
Not available
S-EPMC11328142 | biostudies-literature
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