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ProteomicsProteomic analysis of the aggregated proteins in cerebral vessles from MYPT1SMKO mice
To comprehensively understand the mechanism by which MYPT1 modulates the phenotypic switching of VSMCs after ischemic stroke, the proteins of cortical small vessel from MYPT1SMKO and WT mice subjected to MCAO or sham group were collected for proteomic screening.
ORGANISM(S): Mus musculus (Mouse) 
2021-08-21 | PXD027869 | Pride
Mypt1 Ischemmic stroke Vsmc Bbb 
ProteomicsMouse lung proteomics and S-nitrosoproteomics using LC-MS/MS
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by excessive extracellular matrix deposition and impaired tissue repair. S-nitrosoglutathione reductase (GSNOR, encoded by ADH5) is a key enzyme that regulates protein S-nitrosylation by metabolizing S-nitrosoglutathione...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD061250 | Pride
Mouse Lung Lc-ms/ms 
MetabolomicsPrimary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice with Connexin43 Dominant Negative Mutants

Osteocytes could release some small molecules (≤ 1 kDa) through gap junctions and hemichannels to extracellular environment, such as prostaglandin E2 (PGE2), nitric oxide (NO) and adenosine triphosphate (ATP), which play key roles in transferring signals between bone cells and other tissue cells....

2021-04-14 | MTBLS2358 | MetaboLights
ProteomicsA cell-free platform for characterizing and producing therapeutic bacteriophages against biohazardous and antibiotic-resistant bacteria
Bacteriophages are potent therapeutics against biohazardous bacteria that are rapidly acquiring multidrug resistance. However, routine administration of bacteriophage therapy is currently impeded by a lack of safe phage production methodologies and insufficient phage characterization. We thus develo...
ORGANISM(S): Eggerthella phage P3 Enterobacteria phage T7 Escherichia coli Bacteria 
2022-07-20 | PXD019543 | Pride
E. coli Bacteriophage 
ProteomicsBiophysical and proteomic analyses suggest functions of Pseudomonas syringae pv tomato DC3000 extracellular vesicles in bacterial growth during plant infection
Vesiculation is a process employed by Gram-negative bacteria to release extracellular vesicles (EVs) into the environment. Bacterial EVs contain molecular cargo from the donor bacterium and play important roles in bacterial survival and growth. Here, we describe EV production in plant-pathogenic Pse...
ORGANISM(S): Pseudomonas syringae pv. tomato str. DC3000 
2023-10-24 | PXD023971 | Pride
Pattern-triggered immunity Proteomics Arabidopsis thaliana Nta Pto dc3000 Extracellular vesicles Pti Nanoparticle tracking analysis Evs 
ProteomicsProtein phosphorylation networks in Baylisascaris procyonis revealed by phosphoproteomic analysis
Background: Baylisascaris procyonis is an intestinal ascarid worm that parasitizes in raccoons and causes fatal neural, visceral, and ocular larva migrans in humans. Phosphorylated proteins and protein kinases have been studied as vaccine and drug target candidates against parasitic infections. Howe...
ORGANISM(S): Baylisascaris procyonis 
2025-08-04 | PXD066529 | Pride
Raccoon Liquid chromatography-mass spectrometry Signaling pathway Baylisascaris procyonis Phosphoproteome Function 
ProteomicsMigExpress discovers essential cell migration control genes in non-small cell lung cancer
Cell migration is an essential process in health and disease - especially in cancer metastasis. The difficulty to assess migration in high throughput presents a methodological hurdle - hence, only very few screens revealed factors controlling this important process. Here, we introduce MigExpress as...
ORGANISM(S): Homo sapiens (Human) 
2021-04-20 | PXD022146 | Pride
Proteomics Isobaric labeling Tandem mass tags (tmt) Non-small cell lung cancer (nsclc) Transcriptomics Cell migration 
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
Proteomicsiotin-streptavidin affinity purification mass spectrometry of proteins in human 293T cell using bioinylated Orf9b
COVID-19, caused by the new RNA virus strain SARS-CoV-2, is a serious acute respiratory disease. One of the prominent feature of SARS-COV-2 in terms of immune responses is that it triggers very low level responses of IFN-I in cells or COVID-19 patients. Previously SARS-CoV Orf9b were reported to be ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019803 | Pride
Ap-ms Human 293t cell Silac Sars-cov-2 orf9b 
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