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ProteomicsToxoplasma gondii; protein posttranslational modification; lactylation; metabolism; function
Toxoplasma gondii, a single-celled protozoan parasite (phylum Apicomplexa) and remains the causative pathogen of one of the most wide-spread infectious diseases, toxoplasmosis. To continuously proliferate in warm-blooded animals, this parasite undergoes repeated cycles of invasion, division and indu...
ORGANISM(S): Toxoplasma gondii 
2024-04-07 | PXD022700 | Pride
Toxoplasma gondii 
ProteomicsGlobal lysine crotonylation and 2-hydroxyisobutyrylation in phenotypically different Toxoplasma gondii parasites
Toxoplasma gondii is a unicellular protozoan parasite of the phylum Apicomplexa. The parasite repeatedly goes through a cycle of invasion, division and induction of host cell rupture, which is an obligatory process for proliferation inside warm-blooded animals. It is known that the biology of the pa...
ORGANISM(S): Toxoplasma gondii 
2019-09-09 | PXD014133 | Pride
Metabolism Protein posttranslational modification Toxoplasma gondii Function Crotonylation 2-hydroxyisobutyrylation 
TranscriptomicsGenome-wide transcriptome analysis revealed extensive alternative RNA splicing in gene expression in the zoonotic parasite Schistosoma japonicum
Background: Schistosoma japonicum is a pathogen of the phylum Platyhelminths that causes zoonotic schistosomiasis endemic in China and Southeast Asian countries. Control of the disease has been hampered by the lack of efficient measures. The development of tools for diagnosis of acute and chronic i...
ORGANISM(S): Schistosoma japonicum 
2014-09-02 | E-GEOD-58564 | biostudies-arrayexpress
ProteomicsExploring the molecular mechanism of dihydroartemisinin regulating spleen immunity based on proteomics and phosphoproteomic
The molecular mechanisms through which dihydroartemisinin (DHA) induces immunomodulation in vivo remain unclear. Herein, DHA-regulated proteins and their phosphorylation profiles were identified and characterized, in the spleens of mice, using proteomics and phosphoproteomic approaches. We found tha...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-29 | PXD030353 | Pride
Dihydroartemisinin Phosphoproteomic Proteomics Immunomodulatory activity 
ProteomicsLandscapes of post-translational modifications in Trypanosoma parasites
Proteins of all living cells undergo a myriad of posttranslational modifications (PTMs) that are critical to multifarious life processes. In this study, we describe the first comprehensive multiple PTM-omics atlas in parallel with quantitative proteome analyses of two representative species of trypa...
ORGANISM(S): Trypanosoma brucei brucei 
2020-06-30 | PXD016425 | Pride
Trypanosoma brucei  trypanosoma evansi  post-translational modification  acetylation  crotonyltion  2-hydroxyisobutyrylation  malonylation  succinylation  ubiquitination  trimethylation  phosphorylation  n-glycosylation  o-glcnacylation 
TranscriptomicsGlobal gene expression analysis of the zoonotic parasite Trichinella spiralis revealed novel genes in host parasite interaction
Trichinellosis of human and other mammals was caused through the ingestion of the parasiteM-oM-
ORGANISM(S): Trichinella spiralis 
2013-06-18 | E-GEOD-39151 | biostudies-arrayexpress
ProteomicsDynamic protein modification of the malaria parasite Plasmodium falciparum and the infected erythrocytes
Plasmodium falciparum, a lethal protozoan, undergoes a complex extra- and intraerythrocytic development cycle that requires intricate and flexible regulatory mechanisms in order to facilitate reproduction and maintain the parasite’s resistance to environmental stress. Protein post-translational modi...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2020-11-09 | PXD017503 | Pride
Plasmodium falciparum  infected erythrocytes  intraerythrocytic development cycle  dynamic epigenetics  phosphorylation  acetylation  crotonylation  2-hydroxyisobutyrylation  n-glycosylation  ubiquitination. 
TranscriptomicsS.japonicum Digital Gene Expression
Schistosoma japonicum is one of the remarkable platyhelminths that are endemic in the South Asian countries. The parasite is dioecious and can parasitize inside host blood stream for many years. Rapid reproduction by producing large number of eggs and count-react or active manipulating host anti-par...
ORGANISM(S): Schistosoma japonicum 
2011-12-01 | E-GEOD-26845 | biostudies-arrayexpress
ProteomicsComparative proteomic analysis of ovarian tissue from Huoyan goose between pre-laying period and laying period using iTRAQ-based approach
In this study, we performed a comprehensive evaluation of proteomic profile in ovarian tissues of Huoyan goose during laying period compared to pre-laying period using iTRAQ based approach. 403 proteins which including 255 up-regulated and 148 down-regulated were identified. Subsequently, GO enrichm...
ORGANISM(S): Anser cygnoides 
2022-03-06 | PXD004735 | Pride
Goose Ovary Lc-ms/ms 
ProteomicsComparative proteomic analysis of pituitary tissue from Huoyan goose between pre-laying period and laying period
In this study, we performed a comprehensive evaluation of proteomic profile in the pituitary gland of Huoyan geese during laying period compared to pre-laying period and using iTRAQ based approach. 684 proteins which including 418 up-regulated and 266 down-regulated were identified. Subsequently, GO...
ORGANISM(S): Anser cygnoides 
2018-10-27 | PXD004472 | Pride
Lc-ms/ms Goose Pituitary 
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